Bronchial asthma is a heterogeneous disease that requires identification of its phenotype and personalized approach to therapy. At the same time, despite wide range therapeutic options, many patients with cannot achieve control over disease. Methodology . The target audience these clinical recommendations are general practitioners, therapists, pediatricians, allergologists-immunologists, pulmon...

The arachidonic acid metabolism via 5-lipoxygenase gives rise to a family of biologically active lipids known as leukotrienes. The role of cysteinyl leukotrienes in the pathogenesis of bronchial asthma is well established. Randomized controlled trials (RCTs) have confirmed the efficacy of leukotriene receptor antagonists (LTRAs), when used as monotherapy or added to inhaled corticosteroids (ICS...

In bronchial asthma, respiratory virus infection involves several issues: 1) respiratory virus infection in infancy is a risk factor for, and may predispose to, the development of asthma later in life; 2) respiratory virus infection is associated with the acute exacerbation of bronchial asthma; and, 3) glucocorticosteroids (GC) are not adequate for controlling asthma-related symptoms upon respi...

allergic rhinitis and asthma share common  epidemiological features and inflammatory processes. the aim of the present study was to document the influence of natural allergen exposure in exhaled no  (eno)  and in spirometric parameters of patients with seasonal allergic rhinitis(sar) and to investigate the differences among subjects with positive versus negative bronchial provocation to metacho...

churg strauss syndrome (css) is a form of primary vasculitis that is characterized by severe eosinophilia and often granulomatous inflammation as well as history of asthma or allergy. previously, the association between cysteinyl leukotrien receptor antagonists (ltras), corticosteroid withdrawal or a sudden change in its used method and css had been established. we report three cases that have ...

Bronchial Asthma is defined by the history of respiratory symptoms such as wheeze, shortness breath, chest tightness and cough that vary over time in intensity, together with variable expiratory airflow limitation. Airflow limitation may later become persistent course disease. To compare findings eosinophil counts peripheral blood, induced sputum bronchoalveolar lavage fluid asthmatic patients ...

It is uncommon for bronchial asthma to be a symptom of phaeochromocytoma. We describe a patient with a phaeochromocytoma who presented with worsening of her asthma and persistent dyspnoea between attacks. She had markedly elevated levels of catecholamines. After surgical resection of the phaeochromocytoma there was a lasting improvement of the bronchial asthma. We hypothesize that worsening of ...

Background Asthma and allergic rhinitis have become a growing public health problem. The airflow obstruction, pathophysiological event that frames the bronchial asthma is usually determined by spirometry. Changes in expiratory flow in asthma are well known but there is controversy with these results in allergic rhinitis. The objective of this project is to compare spirometry values of young adu...

Bronchial thermoplasty is an intervention developed for the treatment of asthma through the delivery of radio frequency energy to the airways [1, 2]. Evidence for the efficacy and safety of bronchial thermoplasty in severe asthma is based on the results of three randomised controlled trials [3–5]. Two trials compared bronchial thermoplasty with usual care, the Asthma Intervention Research (AIR)...