BACKGROUND A randomised trial was conducted comparing wide lumpectomy and breast irradiation with modified radical mastectomy. As the follow-up was long (mean duration 22 years), we analysed the variation in the effect of treatment over time. PATIENTS AND METHODS The trial included 179 patients with a breast cancer measuring </=2 cm at macroscopic examination. Eighty-eight patients had breast...

OBJECTIVE: To evaluate ipsilateral breast tumor recurrence after breast-conserving surgery for locally advanced breast cancer. METHODS: A retrospective observational cohort study was performed in patients with locally advanced breast cancer submitted to breast-conserving surgery after neoadjuvant chemotherapy based on an adriamycin-cyclophosphamide-paclitaxel regimen. We evaluated the clinica...

BACKGROUND The optimal sequence of radiotherapy (RT) and hormone therapy using aromatase inhibitors (AI) in patients with breast cancer treated with breast-conserving surgery is unclear. Several short-term analyses have shown that there are no differences in breast cancer outcomes according to the treatment sequence. However, long-term outcomes have not been reported. PATIENTS AND METHODS We ...

Centrally located tumours have long been considered to be more serious, multifocal and more likely to recur. In fact, this is not the case; the only real problem is ensuring that the breast is preserved with a “normal” form following breast-conserving surgery and adjuvant radiotherapy. As with more peripheral tumours, central tumours may also benefi t from breast-conserving surgery. Several tec...

The aim of this study is to discuss indications, advantages, disadvantages, oncologic and aesthetic results of Oncoplastic Surgery (OBS). Pubmed and Medline database were searched for articles published between 1998 and 2014 for keywords: oncoplastic breast surgery, therapeutic mammoplasty, oncoplastic breast reduction, synchrenous reconstructions. Role of OBS in breast cancer surgery, its aspe...

This study is to investigate the accuracy of Sentinel Lymph Node Biopsy (SLNB) in predicting axillary lymph node metastasis and its application in breast conserving surgery for early breast cancer. The clinical data of SLNB of 448 patients were retrospectively analyzed. The patients with negative result of SLNB were not performed with Axillary Lymph Node Dissection (ALND) (experimental group), ...

Objective: To investigate the effect of breast conserving surgery and modified radical operation modified radical operation for early stage breast cancer patients. Methods: A retrospective analysis of 100 cases of early breast cancer patients in our hospital from January 2010 to November 2011 were divided into conserving group (n=50, using breast conserving surgery) and radical group (n=50, usi...

BACKGROUND The surgical approach to breast cancer changed dramatically in the past 20 years. The surgical objective today is to remove the tumor, ensuring negative margins and good cosmetic results, and preserving the breast when possible. Magnetic resonance imaging of the breast has become an essential imaging tool prior to surgery, diagnosing additional tumors and assessing tumor extent. Tumo...

Ductal carcinoma in situ of the breast is associated with low mortality rates, but local relapse is a matter of concern in this disease. Risk factors for local relapse include young age, close or positive margins, and tumor necrosis. Whole breast irradiation following breast-conserving surgery for ductal carcinoma in situ significantly reduces the risk of local relapse as compared to breast-con...