This paper describes the use of a symbolic modeling tool and a methodology we developed for modeling processes in business re-engmeering projects. DECmodel, a symbolic modeling tool, was used to build dynamically activated, working scale models of processes. Models were developed for business, systems, and organizational processes at several levels of detail, and integraled into a large dynamic...

"Breakthrough pain" is a common clinical term that has not been conclusively defined or described. Breakthrough pain is a transitory flare of pain experienced when baseline pain has been reduced to a mild or moderate level. Breakthrough pain may be characterized by its relationship to a fixed around-the-clock (ATC) opioid dose, rapid onset and short duration, precipitating events, predictabilit...

Membrane chromatography (MC) is gaining wider acceptance in downstream processing of biopharmaceuticals. MC offers the advantage of higher operational flow-rates and thus, provides an attractive alternative to traditionally employed packed bed chromatography. With increased commercial usage, in-depth understanding of different mechanisms within MC capsules is desirable in order to achieve optim...

In this work, the adsorption of carbon dioxide from model flue gas on different adsorbents has been investigated. Using simplified modeling, parameters such as the total mass transfer coefficient and the effective diffusivity have been determined. Experiments were carried out in two sections: firstly, adsorption of pure carbon dioxide on different adsorbents was measured at pressures ranging fr...

Among all the modeling approaches dedicated to cellular biology, differential algebra is particularly related to the well-established one based on nonlinear differential equations. In this paper, it is shown that differential algebra makes one of the model reduction methods both simple and algorithmic: the quasi-steady state approximation theory, in the particular setting of generalized chemica...

The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate patient-specific models for the investigation of host-pathogen interactions and to develop new antimicrobial and antiviral therapies. Application...

Modeling the contaminant transport process in soils requires the solute transport parameters. Displacement experiments were carried out on soil columns (Sand – Silt – Clay) by injecting a solution of 0.8 M KCl in a steady state. Breakthrough curves are symmetrical, characteristics of an equilibrium solute transport. The hydrodynamic dispersion coefficients were estimated by optimizing the measu...