Lactoferrin is a versatile protein present in most bodily fluids of mammals. Because more and important functions lactoferrin the human body are being discovered, interest its industrial production application consumer goods increasing accordingly. Today, primarily isolated from bovine milk or sweet whey using cation exchange column chromatography – costly but efficient high-throughput process ...

α s2-casein f(183-207) and lactoferricin [lactoferrin f(17-41)] are two potent 3 antibacterial peptides derived from bovine milk proteins. The aim of this work was to 4 evaluate if the antimicrobial activity of natural compounds employed in food 5 preservation such as nisin could be enhanced by combination with the aforementioned 6 milk peptides. Combinations with lactoferrin were also performe...

Hepatitis C virus (HCV) is associated with the development of cirrhosis and hepatocellular carcinoma. We recently found that bovine lactoferrin, a milk protein belonging to the iron transporter family, effectively prevented HCV infection in cultured human hepatocytes (PH5CH8). We tested the hypothesis that lactoferrin inhibits HCV viremia in patients with chronic hepatitis C. Eleven patients wi...

Human papillomavirus (HPV) cause common warts, laryngeal papilloma and genital condylomata and might lead to development of cervical cancer. Lactoferrin (LF) is a member of the transferrin family, which has antiviral activity against HPV-16. LF is an important player in the defense against pathogenic microorganisms and has also been shown to have activity against several viruses including herpe...

Bovine mammary epithelial cells (bMECs) synthesize lactoferrin, which is secreted into milk. Our results suggest that prolactin stimulated secretion of lactoferrin in primary bMECs and their clonal cell line under serum-free conditions. Prolactin also stimulated mRNA expression of lactoferrin in the clonal cell line. This effect was reduced by AG-490, suggesting that the prolactin-stimulated mR...

Lactoferrin, a glycoprotein present in neutrophils and exocrine secretions, plays important roles in host defense. Administration of bovine lactoferrin has been reported to modulate various neutrophil functions. We found a mixed-breed male dog with novel familial neutrophil dysfunction. The disorder was caused by a decrease of β2-integrin expression encoding CD18 without mutation. Antibiotics t...

The structure of the iron-binding glycoprotein lactoferrin, present in milk and other exocrine secretions, has been elucidated in great detail, both the three-dimensional protein structure and the attached N-glycans. Structure-function relationships are being established. From these studies a function for lactoferrin in host defence and modulation of iron metabolism emerges. This paper describe...

Lactoferrin (LF) is one of the most abundant bioactive glycoproteins in human milk. Glycans attached through N-glycosidic bonds may contribute to Lactoferrin functional activities. In contrast, LF is present in trace amounts in bovine milk. Efforts to increase LF concentration in bovine milk led to alternative approaches using transgenic cows to express human lactoferrin (hLF). This study inves...

Lactoferrin is a major component of breast milk protein, constituting 10-15% of the total content. Each molecule of lactoferrin is capable of binding two atoms of iron and it has been proposed that lactoferrin is involved in iron absorption in the newborn infant. It is known that iron status of exclusively breast-fed infants usually is satisfactory to 6-9 months of age, in spite of a low iron c...

lactoferrin is a glycoprotein with molecular weight 80 kda iron-binding bond, which is composed of 690 amino acids. in most mammalian body fluids such as sweat, semen, tears, and saliva and milk neutrophil granules there. bovine lactoferrin gene be associated with susceptibility/resistance to mastitis and even with some economically important production traits. this study was carried out to det...