Boswellia serrata resin dry extract is among the few herbal remedies designated with an orphan drug status for the treatment of peritumoral brain edema. In addition, boswellic acids (BAs), the main active ingredients of B. serrata extracts, have potent anti-inflammatory properties, and may represent promising agents for the treatment of inflammatory diseases. Pharmacokinetic studies, however, r...

Extracts from the gum resin of Boswellia serrata and some of is constituents including boswellic acids affect the immune system in different ways. Among the various boswellic acids 11-keto-beta-boswellic acid (KBA) and acetyl-11-keto-beta-boswellic acid have been observed to be active. However, also other boswellic acids may exhibit actions in the immune system. In the humoral defence system a ...

The present investigation was aimed to formulate transdermal films incorporating herbal drug components. The allopathic system of medicine includes two conventional lines of treatment for rheumatoid arthritis, which come along with certain side effects. Hence, turning to safe, effective and time-tested Ayurvedic herbal drug formulation would be a preferable option. With this view transdermal fi...

Boswellic acids are the effective components of gum resin of Boswellia serrata, which has anti-inflammatory properties. Recent studies on brain tumors and leukemic cells indicate that boswellic acids may have antiproliferative and apoptotic effects with the mechanisms being not studied in detail. We studied their antiproliferative and apoptotic effects on colon cancer cells and the pathway lead...

prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...

Frankincense (Boswellia serrata, B. carterii) is used as traditional remedy to treat inflammatory diseases. The molecular effects of the active ingredients, the boswellic acids, on the immune system have previously been studied and verified in several clinical studies. Boswellic acids also inhibit cancer cell growth in vitro and in vivo. The molecular basis of the cytotoxicity of boswellic acid...

Boswellia is a genus of shrubs or small/medium trees in which there continued interest number species for their potential medicinal use. . This review aimed to produce ‘map’ research on identify the translation findings across different areas and any gaps. Searches were carried out using major databases vitro, vivo clinical studies condition disease, involving extracts. Data extracted health st...

It seems that frankincense might have a potential ability to be used as an alternative natural medicine not only for cancer, chronic and inflammatory diseases but also for the patients with brain and memory disorders. Frankincense, the resinous extract from the trees of the genus Boswellia, has been used for centuries in ceremonial, cosmetic, cultural and as a traditional medicine to treat a va...

The effect of boswellic acids on bovine serum albumin (BSA)-induced arthritis in rabbits was studied. Oral administration of boswellic acids (25, 50 and 100 mg/kg/day) significantly reduced the population of leucocytes in a BSA-injected knee and changed the electrophoretic pattern of the synovial fluid proteins. The local injection of boswellic acids (5, 10 and 20 mg) into the knee 15 min prior...