Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also contributes to protection against Bordetella pertussis, and it has already been demonstrated that Pa induce T cells that secrete type-1 and type-2 cytokines in children. In this stu...

CONTEXT Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated. OBJECTIVE To determine the effects of cognitive training on daily function and durability of training on cognitive abilities. DESIGN, SETTING, AND PARTICIPANTS Five-year follow-up of a randomized controlled single-bli...

OBJECTIVE To determine the prevalence of latent tuberculosis infection (LTBI) and the risk of infection in patients with chronic kidney disease treated at a hemodialysis center. METHODS We included 307 patients with chronic kidney disease undergoing hemodialysis at the Mineiro Institute of Nephrology, located in the city of Belo Horizonte, Brazil. All of the patients were submitted to tubercu...

Motor vehicle accidents have been the leading cause of death for children and youth for decades. Booster seats are designed to better protect children four to eight years old in the event of an accident, and over the past decade, forty-seven states and the District of Columbia have passed laws mandating their use. In this paper I estimate the effect that booster seat laws have on reducing injur...

BACKGROUND The risk of developing tuberculosis is high among chronic hemodialysis patients. The tuberculin skin test (TST) has been in use for diagnosing latent TB, but few data are available on TST in hemodialysis patients. OBJECTIVE This study was done to identify the TST reactivity and frequency of booster effect in serial TST among hemodialysis patients. METHODS A total of 100 patients ...

The current study explored the benefits of adding booster sessions to a validated and successful self-management intervention for type 2 diabetes patients (i.e. Beyond Good Intentions). Although the addition of booster sessions to self-management interventions is often recommended, it has not been empirically established to what extent booster sessions are in fact appreciated by participants. P...

The aim of the current study is to estimate the epidemiological and economical consequences of several extended pertussis booster vaccination strategies and to explore the impact of parameters surrounded by large uncertainty on the cost-effectiveness. We developed an age structured transmission dynamic model to evaluate the impact of programs targeting (i) adolescents or adults using a single b...

This paper proposes an effective numerical methodology to analyze the mechanism of the separation of an inserted type of solid rocket booster from a supersonic air breathing engine vehicle having a conical intake. Unlike the previous computational fluid dynamic (CFD) approach, present work constructs a compacted model capable to reduce the computational time definitely. The dynamics of vehicle ...

The SPEAR2 accelerator system originally had 3 RF stations (2 for storage ring, 1 Booster) operating at 358.5 MHz. SPEAR3 now operates at 476.3 MHz with the PEPII type RF system, while the Booster RF frequency remains unchanged. For top-off operation, the Booster injects single 3.0 GeV electron bunches into SPEAR3 at 10 Hz every 5 minutes to replenish lost charge. Due to the frequency mismatch ...

UNLABELLED Here we report the first evaluation of T-cell responses upon a second acellular pertussis booster vaccination in Dutch children at 9 years of age, 5 years after a preschool booster vaccination. Blood samples of children 9 years of age were studied longitudinally until 1 year after the second aP booster and compared with those after the first aP booster in children 4 and 6 years of ag...