نتایج جستجو برای: bone resorption

تعداد نتایج: 308911  

Journal: :Molecular biology of the cell 2003
M A Chellaiah N Kizer R Biswas U Alvarez J Strauss-Schoenberger L Rifas S R Rittling D T Denhardt K A Hruska

Osteopontin (OPN) was expressed in murine wild-type osteoclasts, localized to the basolateral, clear zone, and ruffled border membranes, and deposited in the resorption pits during bone resorption. The lack of OPN secretion into the resorption bay of avian osteoclasts may be a component of their functional resorption deficiency in vitro. Osteoclasts deficient in OPN were hypomotile and exhibite...

Journal: :iranian red crescent medical journal 0
ferhat ayranci department of oral maxillofacial surgery, faculty of dentistry, ordu university, ordu, turkey; department of oral maxillofacial surgery, faculty of dentistry, ordu university, 52200, ordu, turkey. tel: +90-4522125005, fax: +90-4522121289 metin gungormus department of oral and maxillofacial surgery, faculty of dentistry, gaziantep university, gaziantep, turkey mehmet melih omezli department of oral maxillofacial surgery, faculty of dentistry, ordu university, ordu, turkey betul gundogdu department of pathology, faculty of medicine, ataturk university, erzurum, turkey

conclusions alendronate may be considered a therapeutic option for improving the bone formation process and reducing resorption in different bone grafting procedures. further detailed studies should focus on dosage and time-dependent effects of alendronate on bone remodeling. results at 6 weeks, the bone area was significantly larger in the xenograft-alendronate group (33.0% ± 5.0%) than in the...

Journal: :Journal of pharmacological sciences 2012
Tsukasa Tominari Michiko Hirata Chiho Matsumoto Masaki Inada Chisato Miyaura

Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the anti-inflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor...

Journal: :The Journal of clinical investigation 1987
P M McSheehy T J Chambers

Although 1,25-dihydroxyvitamin D3 stimulates osteoclastic bone resorption in vivo and in organ culture, the mechanism by which it effects this stimulation is unknown. We have recently found that the agent does not stimulate resorption by osteoclasts mechanically disaggregated from bone and incubated on slices of cortical bone. This suggests that the osteoclasts were removed by disaggregation fr...

Background and purpose: Internal inflammatory root resorption (IIRR) is an uncommon lesion in permanent tooth that could lead to destruction of root and the surrounding dental hard tissues if it is left untreated. This article describes treatment of an extensive perforating internal root resorption in a maxillary second premolar using mineral trioxide aggregate (MTA). Case report: After chem...

2011
Romain Dacquin Chantal Domenget Atsushi Kumanogoh Hitoshi Kikutani Pierre Jurdic Irma Machuca-Gayet

Osteoporosis is one of the most common bone pathologies, which are characterized by a decrease in bone mass. It is well established that bone mass, which results from a balanced bone formation and bone resorption, is regulated by many hormonal, environmental and genetic factors. Here we report that the immune semaphorin 4D (Sema4D) is a novel factor controlling bone resorption. Sema4D-deficient...

Journal: :Advances in medical sciences 2006
J Małyszko J S Małyszko K Pawlak S Wołczyński M Myśliwiec

PURPOSE Renal osteodystrophy is a common complication of chronic renal failure and renal replacement therapy. Successful kidney transplantation reverses many of these abnormalities, however, the improvement is often incomplete. The osteoclast specific 5b isoform of tartrate-resistant acid phosphatase (TRAP) 5b has recently been proposed a specific and sensitive marker of bone resorption. The ai...

Journal: :Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 2012
Marco Duvina Luigi Barbato Leila Brancato Giovanna Delle Rose Franco Amunni Paolo Tonelli

Osteoporosis is a systemic disease in which the skeletal condition is characterized by a decreased mass of normally mineralized bone, due to an augmentation of bone resorption processes. Bone biomarkers serum are used for the diagnosis. On the other hand the main cause of the resorption in the bone jaws are periodontitis, inflammatory cysts, developmental cysts, odontogenic neoplasms. Periodont...

Journal: :Journal of pharmacological sciences 2006
Masaki Noda

Bone formation in adults determines the basic mass of bone and hence it is crucial to understand the mechanisms of its regulation. As remodeling is proceeding, bone resorption is determined by the physical conditions. Especially in women, postmenopausal bone loss is characterized by rapid bone loss due to increase in bone resorption and relative negative balance between such bone resorption and...

2011
Baohong Zhao Lionel B Ivashkiv

Bone remodeling in physiological and pathological conditions represents a balance between bone resorption mediated by osteoclasts and bone formation by osteoblasts. Bone resorption is tightly and dynamically regulated by multiple mediators, including cytokines that act directly on osteoclasts and their precursors, or indirectly by modulating osteoblast lineage cells that in turn regulate osteoc...

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