introduction: involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. although th...

Dominique Heymann, Professor, Faculty of Medicine, University of Nantes Head of. What does it mean when you have bone metastases? This is a common approach to hormone therapy for.Primary Bone Cancers and Bone Metastases. Chapter 34 Therapeutic approaches for bone sarcomas.almost always develop bone metastases, and the chances are high that, in. Table 1 Approaches to treating bone metastases. Re...

thallium 201 whole body scintigraphy was performed in a 30 year old patient with diffuse osseous metastatic disease secondary to glioblastoma multiforme. multiple sites of thallium uptake correlated with the findings on serial bone scans and radiographs. bone biopsy of a lower lumbar vertebra confirmed that the metastases were of glial origin.

Several biochemical markers of bone formation and bone resorption have recently been developed. These markers have been evaluated for clinical utility in patients with metabolic bone disease, including Paget disease and osteoporosis, and for their potential use in cancer patients whose disease has metastasized to bone. We have evaluated seven markers of bone turnover in the plasma and urine of ...

The features of Hypertrophic pulmunary osteoarthropathy (HPOA) on radionuclide bone scintigraphy have been well described in case reports and small series of patients. The aim of this study was to investigate prospectively the prevalence and distribution of HPOA in a large series of patients with carcinoma of the lung. Two hundred and eleven patients aged 31-89 years (average age 66 years...

The benefits of bisphosphonates (BPs) in reducing skeletal-related events (SREs) in patients with bone metastases has mainly been attributed to their potent osteoclast inhibiting effect. However, despite the use of modern systemic anticancer therapy including potent BPs, many patients with bone metastases continue to have SREs. An improved understanding of the fundamental mechanisms of bone des...

OBJECTIVE To see whether parathyroid hormone related protein has a humoral role in breast cancer. DESIGN Plasma concentrations and tumour expression of parathyroid hormone related protein were determined (by two site immunoradiometric assay and immunohistochemistry respectively) in women with breast cancer and related to the presence of bone metastases and serum calcium concentrations. SUBJ...

The vast majority of patients with metastatic castration-resistant prostate cancer (mCRPC) develop bone metastases. Bone metastases are a source of significant morbidity and affect quality of life in these patients. Several bone-targeting agents are approved for the treatment of bone metastases in prostate cancer, including bisphosphonates, denosumab, and radiopharmaceuticals. Radium-223 is a n...

BACKGROUND Bone metastases cause morbidity and mortality in multiple malignancies. In addition to portending a dire prognosis, bone metastases cause bone pain, fractures, hypercalcemia, spinal cord compression, and other nerve compression syndromes. Improved understanding of the mechanisms that predispose tumor metastases to bone is needed to improve patients' therapeutic options, maintain thei...

Background. The aim of this study was to show the importance of the bone marker procollagen type 1 aminoterminal propeptide (P1NP) in detecting bone metastases in women suffering from breast cancer. We furthermore investigated to what degree P1NP is correlated to the degree of bone metastases, and if P1NP is increased in patients with metastases other than bone. Patients and Methods. We analyze...