We report a case of bone marrow necrosis preceding infantile acute lymphoblastic leukaemia (ALL). Bone marrow necrosis is a rare antemortem event and has been known to be present in many conditions, notably in haematological malignancies like acute lymphoblastic leukaemia. This case was a 6-month-old Chinese boy who was referred to Hospital Universiti Kebangsaan Malaysia for further investigati...

Bone marrow necrosis is a rare but ominous finding in various malignant and nonmalignant disorders. It is usually a postmortem diagnosis, but with the advent of modern imaging methods and clinical suspicion, bone marrow necrosis can be diagnosed as antemortem, especially in malignant disorders. We report a 60-years old man with newly diagnosed non-Hodgkin lymphoma presenting with anemia and ver...

Bone marrow edema is not the major component of histological anomalies in most situations. For this reason, some authors prefer “bone marrow edema-like” signal or abnormalities.2 Its physiopathology is unclear and varies with the underlying pathological condition. Bone marrow edema may be apparent in a variety of anomalies that correspond to their etiologies (e.g., necrosis, fibrosis, hemorrhag...

NONUNION FRACTURES AND ASEPTIC BONE NECROSIS ARE TWO PATHOLOGICAL CONDITIONS HAVING SOME IMPAIRMENT OF THE CELLULAR PART OF THE REPAIR: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direc...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 47-year-old woman visited our hospital complaining of recently developed back pain. Complete blood cell counts cells. Her bone marrow (A) (H&E, ×400) was packed with blasts, which were positive for CD34, CD19, CD20, CD10, and TdT. The diagnosis of precurso...

The proximal metaphyses of the humerus of weanling gnotobiotic dogs experimentally infected with canine distemper virus (CDV) were investigated histologically and immunocytochemically between 4 and 41 days after infection. Viral antigen was demonstrated in hematopoietic marrow and bone cells at postinfection day (PID) 5 and PID 7, respectively. Between PID 8 and 27, CDV antigen was abundantly p...