Bone marrow lesions (BMLs) are areas of high-signal-intensity on magnetic resonance imaging (MRI) with an unknown pathogenesis. Currently, BMLs thought to be due a range etiologies including chondral defects, fractures, and inflammation. One treatment option for is subchondroplasty procedure. However, limited data available analyzing patient reported outcomes (PROs) after this procedure, especi...

INTRODUCTION There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA). However, there is a lack of long term data. The aim of this study was to describe the natural history of knee BMLs, their association with knee pain and examine predictors of BML change over eight years. METHODS A total of 198 subjects (109 adult off...

OBJECTIVE To determine the effect of chondroitin sulphate (CS) treatment on cartilage volume loss, subchondral bone marrow lesions (BML), synovitis and disease symptoms in patients with knee osteoarthritis (OA). METHODS In this pilot multicentre, randomised, double-blind, controlled trial in primary knee OA, 69 patients with clinical signs of synovitis were randomised to receive CS 800 mg or ...

Background: Bone marrow lesions (BMLs) are associated with osteoarthritis (OA). We assessed the performance of two commonly used MRI sequences, IW-TSE and DESS, for reliability in the detection of BMLs and sensitivity to estimate change over time. We suggested that the IW-TSE would demonstrate higher sensitivity to change than DESS in the assessment of BML prevalence and change over time. This ...

Background: Mechanical foot pain is a syndrome in which local pain is associated with musculoskeletal tissues, occurring as a result of mechanical stress. Recent research has indicated that bone marrow lesions (BML) in the knee are associated with mechanical knee pain and increased forces, and that changing the forces within the knee can alter the pattern of BML. As foot orthoses are thought to...

The purpose of this prospective case series was to determine the effectiveness using a combination core decompression and injection autologous conditioned plasma (ACP) for treatment symptomatic knee bone marrow lesions (BML), as well report on preliminary clinical results based magnetic resonance imaging (MRI) patient-reported outcomes (PROMs). Patients with OA-related BML who failed improve co...

A 76-year-old man with symptomatic bone metastases from castrationresistant prostate cancer underwent Radium-223-dichloride (Ra-223) therapy. Before Ra-223 therapy, he had normal peripheral blood cell counts. Ra-223 therapy relieved his shoulder and low back pain. The elevation of the serum prostate-specific antigen (PSA), doubling every month during Ra-223 therapy, suggested a PSA flare or rel...

INTRODUCTION There are conflicting data on the natural history and clinical significance of bone marrow lesions (BMLs). The aims of this study were to describe the natural history of MRI-detected BMLs at the knee using a quantitative measure and examine the association of BMLs with pain, function and stiffness scores, and total knee replacement (TKR) surgery. METHODS A total of 395 older male...

OBJECTIVE Subchondral bone attrition (SBA) is defined as flattening or depression of the osseous articular surface. The causes of attrition are unknown, but remodeling processes due to chronic overload that are reflected as bone marrow edema-like lesions (BMLs) on magnetic resonance imaging (MRI) might predispose the subchondral bone to subsequent attrition. The aim of this study was to evaluat...

OBJECTIVE Braces used to treat (PF) osteoarthritis (OA) may reduce contact stress across the PF joint. We hypothesised that in PF OA, braces would decrease knee pain and shrink PF bone marrow lesions (BMLs). METHODS Eligible subjects had painful PF OA. Subjects were randomly allocated to brace or no brace for 6 weeks. Knee MRIs were acquired at baseline and 6 weeks. We measured BMLs on post-c...