Background Bone marrow transplantation (BMT)is nowadays used in various hematological disorders including leukemias. Hemophilia A & B are sex linked bleeding disorders in which there are various genetic abnormalities in factor VIII & IX genes. Among various hematological disorders, bleeding disorders mainly hemophilia in now widely treated using plasma derived and recombinant factor VIII & IX ...

There is considerable interest in the physiology and pathology, as well as the cellular and molecular biology, of bone marrow adipose tissue (BMAT). Because bone marrow adiposity is linked not only to systemic energy metabolism, but also to both bone marrow and musculoskeletal disorders, this biologic compartment has become of major interest to investigators from diverse disciplines. Bone marro...

Gelatinous bone marrow transformation (GMT) is a rare disorder characterized by the presence of fat cell atrophy, loss of hematopoietic cells, and deposition of extracellular gelatinous materials. GMT is not a specific disease, but is strongly associated with malnutrition and drugs. Albeit extremely rare, GMT has been reported in patients with myeloproliferative disorders. Herein, we report the...

Myelofibrosis (MF) is a rare disorder that classified as one of the myeloproliferative disorders. It BCR-ABL1- negative neoplasm characterized by abnormal proliferation hemopoietic stem cells within bone marrow, which leads to overproduction fibrous tissue. Our patient young girl 17 year old presented with lump in left upper abdomen, shortness breath & generalized swelling. The diagnosis wa...

A number of noninvasive imaging techniques have been used for the evaluation of bone marrow, including magnetic resonance imaging (MRI) and bone marrow scintigraphy. The appearance of bone marrow on MRI varies considerably depending on the proportion of red and yellow marrow, and the composition of the red marrow and its distribution with relation to age and sex. The composition of bone marrow ...

Background: Hematological disorders are found commonly in the general population existing on both ends of spectrum with minute like iron deficiency anemia to as severe bone marrow infiltration Objective: To assess frequency hematological malignancies based bone-marrow aspiration and trephine biopsy patients presenting tertiary care hospital Methodology: The current study was cross-section descr...

Objective(s):Sea cucumber derived bioactive compound is considered efficient in treatment of bone disorders. This study was performed   to evaluate the effect of this extract on differentiation of rat bone marrow mesenchymal stem cells (rBMMSc) into osteogenic lineage. Materials and Methods: Isolated rBMMSc were grown in DMEM supplemented with 10% FBS. The cells were exposed to different concen...

  SUMMARY Up to 15 years ago, bone marrow transplantation was experimental, but in the recent years it has gained an important role in the field of Medicine, and it has clearly been established as a therapeutic modality for a wide range of diseases. During 1950-1955 when marrow transplant was first attempted in human, little was known about transplant antigens. Supportive care techniques such...