Biomarkers are essential tools in clinical research and practice. Useful biomarkers must combine good measurability, validated association with biological processes or outcomes, and should support clinical decision making if used in clinical practice. Several types of validated biomarkers have been reported in the context of bone diseases. However, because these biomarkers face certain limitati...

Introduction: Acute lymphoblastic leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL) are the most common childhood and adolescence malignancy respectively.Due to the increasing survival of these children, today late side effects of treatments are important. Therapies such as corticosteroids, cytotoxic and radiotherapy effect on bone density and put the child at risk of osteoporosis and pathologi...

abstract introduction : conjugated linoleic acid (cla) has been shown to positively influence on calcium and bone metabolism in experimental animals and cell culture, but there are limited human data available. material and methods : this double-blind, placebo-controlled trial study was done on 76 healthy post-menopausal women (aged 55.1) which randomly assigned to receive daily four cla capsul...

Multiple myeloma (MM) is a bone marrow neoplasia that causes pain in 70% patients. While preclinical models of MM have suggested both nerve sprouting and injury may be causative for the pain, there lack clinical data. Thus, primary aims this study are: (1) to provide deep characterization subjective experience quality life patients; (2) investigate disturbances innervation Secondary include exp...

osteopontin also known as bone sialoprotein (bsp). osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. osteoprontin (opn) binds to several integrin receptors containing α4β1, α9β1, and α9β4 expressed by leukocytes. these receptors have been well-stable to function in cell adhesion, migration, and survival in these cells. i...

Osteopontin also known as bone sialoprotein (BSP). Osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. Osteoprontin (OPN) binds to several integrin receptors containing α4β1, α9β1, and α9β4 expressed by leukocytes. These receptors have been well-stable to function in cell adhesion, migratio...

Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...