Revision total hip replacement has a failure rate of up to 25%. Part of the reason for this high failure is the lack of bone stock. In this study, we investigated whether mesenchymal stromal cells (MSCs) or osteoprogenitors (OPs) contribute to bone formation in impacted allograft or an allograft and hydroxyapatite (HA) combination. Eight samples were inserted in the paraspinal muscles of six sh...

BACKGROUND Obtaining intraoperative cultures of allograft bone just before use in orthopedic procedures is standard practice in many centres; however, the association between positive cultures and subsequent surgical infections is unknown. Our study had 3 goals: to determine the prevalence of positive intraoperative allograft culture and subsequent infection; to determine if, in cases of subseq...

Markedly elevated111 In labeled leukocyte activity suggestive of acute osteomyelitis was observed in a region of a composite mandibular allograft that was photon deficient on 99mTc MDP bone scintigraphy. This finding was later confirmed by surgical pathology. The patient was treated with intravenous antibiotics and returned two months later with persistent bone infection. The foHow-up thr...

PURPOSE This study tested a bone-tendon allograft versus human dermis patch for reconstructing chronic rotator cuff repair by use of a canine model. METHODS Mature research dogs (N = 15) were used. Radiopaque wire was placed in the infraspinatus tendon (IST) before its transection. Three weeks later, radiographs showed IST retraction. Each dog then underwent 1 IST treatment: debridement (D), ...

In each femoral condyle of 8 Labrador dogs, a non weight-bearing hydroxyapatite-coated implant was inserted surrounded by a 3 mm gap. Each gap was filled with bone allograft or ProOsteon with or without OP-1 delivered in a bovine collagen type I carrier (OP-1 device). 300 microg OP-1 was used in the 0.75 cc gap surrounding the implant. After 3 weeks, the OP-1 device enhanced implant fixation by...

background and aims. complete and predictable regeneration of tissue lost as a result of infection or trauma is the ultimate goal of periodontal therapy. various graft materials have been successfully used in the treatment of intrabony defects. the purpose of this study was to evaluate the use of a decalcified freeze-dried bone allograft (cerabone) with the autogenous bone graft as a gold stand...

INTRODUCTION: Allograft reconstruction after resection of primary bone sarcomas has a non-union rate of approximately 20%. Achieving a wide surface area of contact between host and allograft bone is one of the most important factors to help reduce the non-union rate. We developed a novel technique of haptic robot-assisted surgery to reconstruct bone defects left after primary bone sarcoma resec...

INTRODUCTION This study evaluated the effect of autologous bone marrow derived adult Mesenchymal Stem Cells (MSCs) on the biological healing of weight bearing diaphyseal bone allograft in the tibia of adult rabbits. MATERIALS AND METHODS Forty Adult New Zealand White Rabbits divided into 3 groups (Autograft, Allograft or Allograft impregnated with MSCs) with 12 rabbits in each group were used...

Background. To achieve success in the incorporation of allografts and bone recipient, many factors are taken into account, which can be divided two main groups: those related to sterilization processing allograft affecting reliability implant fixation recipient. The second important factor is method for fixing purpose was determine mechanical properties after segmental alloplasty. Materials met...

Objective: To assess the effect of low-level laser therapy (LLLT) on morselized bone allograft incorporation. Material and Methods: Four rabbits were used as bone tissue donors. Morselized bone allografts and autografts were placed into the calvaria of 20 rabbits divided across four groups: two LLLT groups (allograft, autograft and blood clot) and two non-irradiated control groups (allograft, a...