In this paper, we apply model predictive control (MPC) for control of blood glucose in people with type 1 diabetes. The two first control strategies are based on nonlinear model predictive control (NMPC). The first control strategy is based on meal announcement in advance, while the second one considers meal announcement at mealtimes only. They give a quantitative upper bound on the achievable ...

Carbohydrate counting (CC) is a meal-planning tool for patients with type 1 diabetes (T1D) treated with a basal bolus insulin regimen by means of multiple daily injections or continuous subcutaneous insulin infusion. It is based on an awareness of foods that contain carbohydrates and their effect on blood glucose. The bolus insulin dose needed is obtained from the total amount of carbohydrates ...

BACKGROUND The Advanced Bolus Calculator for Diabetes (ABC4D) is an insulin bolus dose decision support system based on case-based reasoning (CBR). The system is implemented in a smartphone application to provide personalized and adaptive insulin bolus advice for people with type 1 diabetes. We aimed to assess proof of concept, safety, and feasibility of ABC4D in a free-living environment over ...

BACKGROUND In a previous study we demonstrated improvement in metabolic control and reduction in hypoglycemia in people with type 1 diabetes on multiple daily injections, after having used a bolus calculator for 4 months. OBJECTIVE To demonstrate whether (1) extending its use (2) or introducing it in the control group, previously subjected to treatment intensification, could further improve m...

Corresponding Author: Tomasz Klupa, M.D., Ph.D., Department of Metabolic Diseases, Jagiellonian University, 15 Kopernika St., 31-501 Kraków, Poland; email address [email protected] Two regimens of insulin therapy are used to achieve the goal of near normoglycemia: multiple daily injections (MDI) and continuous subcutaneous insulin infusion (CSII).1 Due to the apparent improvement in qualit...