Meta analysis studies show important effects of cognitive therapy and behavioural therapy for OCD, but further knowledge about resource saving formats such as group therapy is needed and there are only few relevant studies available. We developed a manual for cognitive-behavioural group treatment of patients with OCD. Twenty four patients from a clinical population participated in this naturali...

BACKGROUND This study aimed to assess the efficacy of topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (OCD) as an adjunct to serotonin reuptake inhibitors (SRIs). MATERIALS AND METHODS Thirty-eight patients with refractory OCD, were randomly assigned to receive topiramate or placebo. This study was designed as a 12 weeks, double-bli...

Despite the frequent use of the Yale-Brown Obsessive-Compulsive Scale-Symptom Checklist (Y-BOCS-SC; Goodman et al., 1989a) and the Obsessive-Compulsive Inventory-Revised (OCI-R; Foa et al., 2002), there are limited data on the psychometric properties of the two instruments. In the present research, clinician ratings on the Y-BOCS-SC for 112 patients with obsessive-compulsive disorder (OCD) were...

Objective: This study aims to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) treatment in a group treatment-resistant obsessive-compulsive disorder (OCD) patients and examine relationship between various sociodemographic clinical variables response. Materials Methods: Data including The Yale–Brown Obsessive Compulsive Scale (Y-BOCS) scores characteristics 27 OCD ...

BACKGROUND International guidelines recommend Cognitive Behavior Therapy (CBT) as the first line treatment for pediatric obsessive-compulsive disorder (OCD). However, a substantial proportion of patients do not have access to such treatment. We developed and tested the feasibility, efficacy and acceptability of a novel therapist-guided, Internet-delivered CBT (ICBT) platform for adolescents wit...

Background: Early psychiatrists inferred that obsessive-compulsive symptoms (OCS) represent a defense against psychosis and prevent the progression of schizophrenia. However, recent clinical research has yielded inconsistent results across studies regarding link between OCS symptom domains schizophrenia influence have on patient’s functioning quality life (QOL). This study aimed to determine wh...

The recent development of bone-on-chips (BOCs) holds the main advantage requiring a low quantity cells and material, compared to traditional In Vitro models. By incorporating hydrogels within BOCs, culture system moved three dimensional environment for which is more representative bone tissue matrix function. fundamental components hydrogel-based namely cellular sources, hydrogel chamber, have ...

Objectives In two Phase III studies, lisdexamfetamine dimesylate (LDX) reduced binge eating (BE) days/week in adults with moderate to severe binge eating disorder (BED) and was associated with improvement based on the Clinical Global Impressions-Improvement (CGI-I) scale. In this study, post hoc analyses examined the relationships between clinical observations and clinical rating scales in indi...

IMPORTANCE It is unclear whether d-cycloserine (DCS), a partial N-methyl-d-aspartate agonist that enhances fear extinction, can augment the effects of exposure-based cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD). OBJECTIVES To examine whether DCS augments the effects of CBT for OCD and to explore (post hoc) whether concomitant antidepressant medication moderates t...

A primary goal of the 1996 Telecommunications Act is to encourage competition in longdistance telephone markets. Four years after passage of this legislation, Bell Operating Companies (“BOCs”) have been granted permission to offer long-distance services in only one state. The regulatory barrier to entry is justified on grounds that the BOCs have the ability to discriminate against incumbent lon...