نتایج جستجو برای: bmp

تعداد نتایج: 8738  

Journal: :The Journal of steroid biochemistry and molecular biology 2015
Takeshi Hosoya Fumio Otsuka Eri Nakamura Tomohiro Terasaka Kenichi Inagaki Naoko Tsukamoto-Yamauchi Takayuki Hara Kishio Toma Motoshi Komatsubara Hirofumi Makino

BMPs expressed in the ovary differentially regulate steroidogenesis by granulosa cells. BMP-9, a circulating BMP, is associated with cell proliferation, apoptosis and differentiation in various tissues. However, the effects of BMP-9 on ovarian function have yet to be elucidated. Here we investigated BMP-9 actions on steroidogenesis using rat primary granulosa cells. BMP-9 potently suppressed FS...

Journal: :Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999
M Sato T Ochi T Nakase S Hirota Y Kitamura S Nomura N Yasui

Bone lengthening with osteotomy and gradual distraction was achieved in 57 rats, and the effect of mechanical tension-stress on gene expression of bone morphogenetic proteins (BMPs) was investigated by in situ hybridization and Northern blot analysis using probes of BMP-2, BMP-4, BMP-6, BMP-7, and growth/differentiation factor (GDF)-5. There was a lag phase for 7 days after femoral osteotomy un...

2010
Jin-Li Zhang Lucy J. Patterson Li-Yan Qiu Daria Graziussi Walter Sebald Matthias Hammerschmidt

BACKGROUND Crossveinless-2 (CV2) is an extracellular BMP modulator protein of the Chordin family, which can either enhance or inhibit BMP activity. CV2 binds to BMP2 via subdomain 1 of the first of its five N-terminal von Willebrand factor type C domains (VWC1). Previous studies showed that this BMP binding is required for the anti-, but not for the pro-BMP effect of CV2. More recently, it was ...

2010
Shinji Kuroda Nobuhiro Goto Michiko Suzuki Kazutaka Kaneda Keiichi Ohya Hitoyata Shimokawa Shohei Kasugai

Members of the bone morphogenetic protein (BMP) family have diverse physiological roles. For instance, BMP-2 stimulates osteogenesis, while BMP-12 induces the formation of tendon/ligament-like tissues. Here, we designed a study to determine whether BMP-12 has bone and/or cartilage regeneration abilities similar to those of BMP-2. We implanted plasmid vectors encoding either BMP-2 or BMP-12 in r...

Journal: :The Journal of biological chemistry 2008
Karen Lavery Pamela Swain Dean Falb Moulay Hicham Alaoui-Ismaili

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily of growth factors and are used clinically to induce new bone formation. The purpose of this study was to evaluate receptor utilization by BMP-2, BMP-4, BMP-6, and BMP-7 in primary human mesenchymal stem cells (hMSC), a physiologically relevant cell type that probably mediates the in vivo effects of...

Journal: :The Biochemical journal 2015
Rachel H Church Arjun Krishnakumar Annika Urbanek Stefan Geschwindner Julie Meneely Alessandro Bianchi Barbro Basta Sean Monaghan Christopher Elliot Maria Strömstedt Neil Ferguson Finian Martin Derek P Brazil

Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during diabetic nephropathy (DN) has been suggested to be binding and inhibition of BMP-7. However, the precise interacti...

Journal: :Blood 2008
Yin Xia Jodie L Babitt Yisrael Sidis Raymond T Chung Herbert Y Lin

Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism. However, the precise combinations of BMP ligands and receptors used by HJV remain unknown. HJV has also been demonstrated to bind to neogenin, but it is not known whether this interaction has a role in regulating hepcidin expression. In the present study, we s...

2014
Yinghua He Ying Cui Baiying Xu Jun Gu Wei Wang Xiaoying Luo

BACKGROUND In the liver, bone morphogenetic protein 6 (BMP-6) maintains balanced iron metabolism. However, the mechanism that underlies greater BMP-6 expression in hepatocellular carcinoma (HCC) tissue than adjacent non-cancerous tissue is unclear. This study sought to investigate the epigenetic mechanisms of BMP-6 expression by analysing the relationship between the DNA methylation status of B...

Journal: :Endocrinology 2003
Xuefeng Li Edward M Schwarz Michael J Zuscik Randy N Rosier Andreia M Ionescu J Edward Puzas Hicham Drissi Tzong-Jen Sheu Regis J O'Keefe

Whereas bone morphogenetic protein (BMP)-signaling events induce maturational characteristics in vitro, recent evidence suggests that the effects of other regulators might be mediated through BMP-signaling events. The present study examines the mechanism through which retinoic acid (RA) stimulates differentiation in chicken embryonic caudal sternal chondrocyte cultures. Both RA and BMP-2 induce...

Journal: :Molecular vision 2002
Robert J Wordinger Rajnee Agarwal Mihir Talati John Fuller Wendi Lambert Abbot F Clark

PURPOSE Bone morphogenetic proteins (BMPs) are multi-functional cytokines that have wide ranging effects on a variety of cells and tissues. In the present study, we profile the expression of BMPs, BMP receptors, and BMP associated proteins in the human trabecular meshwork (TM) and optic nerve head (ONH), two tissues involved in glaucoma pathogenesis. METHODS Total RNA was isolated and subject...

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