background recombinant activated factor vii (rfviia; novoseven® rt, novo nordisk, bagsvaerd, denmark) is a synthetic pro-coagulation factor derived from hamster kidney cells. objectives the purpose of this study was to evaluate the prescribing patterns of recombinant factor viia (rfviia) at a single, tertiary care pediatric hospital by indication of usage and dose administered. materials and me...

Blood coagulation is a critical hemostatic process that must be properly regulated to maintain a delicate balance between bleeding and clotting. Disorders of blood coagulation can expose patients to the risk of either bleeding disorders or thrombotic diseases. Coagulation diagnostics using whole blood is very promising for assessing the complexity of the coagulation system and for global measur...

Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease which mediated by various molecular and cellular immune components However Recent reports have shown that coagulation factors that traditionally separate from the immune system might also be involved in MS development and progression.studies on experimental autoimmune encephalomyelitis (EAE) and human MS patients reports alterati...

CONTEXT There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders...

The blood is a very complex organ in our body and coagulation, in particular, is coordinated by various mechanisms. It is known from experience that in order to truly learn and comprehend the different coagulation processes and disorders, most medical students take much time and great pains. The topic is often regarded as not comprehensible and very abstract. This article is supposed to provide...

Initiation of blood coagulation by tissue factor (TF) is a robust, highly regulated process. Both the spatial distribution of TF and the geometry of the vasculature may play important roles in regulating coagulation. As this review describes, microfluidic systems provide a unique opportunity for investigating the spatiotemporal dynamics of blood coagulation in vitro. Microfluidic systems with s...

Thrombotic disorders, such as myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis, pulmonary embolism, or other embolic diseases that are responsible for worldwide mortality and morbidity, are manifestations of the formed thrombi by blood clots during a pathologic blood coagulation process. Once thrombi are formed, the only way to resolve the blood clot i...

The blood is a very complex organ in our body and coagulation, in particular, is coordinated by various mechanisms. It is known from experience that in order to truly learn and comprehend the different coagulation processes and disorders, most medical students take much time and great pains. The topic is often regarded as not comprehensible and very abstract. This article is supposed to provide...

Coagulation disorders concern a deficiency of the body’s functional ability to regulate blood clotting (Peyvandi and Mannucci, 1999). Disorders in thisarea, which may be genetic or acquired, will result in hemostasis-related problems, including different clinical syndromes from easy bleeding or bruising (so-called “hemophilia”) to inappropriate thrombosis (so-called “thrombophilia”; Weisberg, 1...