Naphthalene cataract is probably due to peroxide production through naphthoquinone (NQ) redox cycling and/or glutathione conjugation. Both mechanisms yield losses of essential SH-groups in cristallins and are thus probably involved in protein modification finally visible as lens opacity. 1,2-Naphthoquinone produces H2O2 in the presence of either ascorbate, glutathione, NADH or--to a lesser exte...

In the production of biological effects such as vesication by bis-p-chloroethyl sulfide (mustard gas) it has been considered probable that inactivation of tissue enzymes is of foremost importance. In view of the reaction characteristics of bis-p-chloroethyl sulfide it has appeared likely that this inhibition is due to an alkylation reaction involving essential groups of the enzymes. Involvement...

In the present study, an appropriate synthetic route was adopted to produce the target synthesis of Juglone. In the first of these objectives, 5-nitro-1,4-naphthoquinone had been synthesized by direct nitration of 1,4-naphthoquinone in the presence of water and sulfuric acid. Then the intermediate synthesis of 5-amino-1,4-naphthoquinone was obtained by the reduction of nitro. Finally, Juglone w...

In our continuing search for novel antiplatelet, antiallergic, and antiinflammatory agents, 2-alkoxy derivatives of 1,4-naphthoquinone were prepared. Some of these compounds showed significant antiplatelet, antiallergic, and antiinflammatory activities. Among them, 2-propoxy-1,4-naphthoquinone and 2-butoxy-1,4-naphthoquinone exhibited potent inhibitory effect on neutrophil superoxide anion form...

Background: The rise of antibiotic-resistant Mycobacterium tuberculosis strains has accelerated the hunt for novel drugs (TB). Objectives: This study identified a compound with strong anti-TB efficacy against several resistant M. from chemical library naphthoquinone derivatives. Methods: was designated as MDN-6 (methyl-1,4-bis(2-(diethylamino)ethoxy)-2-naphthoate). Results: It significantly inh...

The reaction of 2-acetyl- and 2-benzoyl-1,4-naphthoquinone with (Z)-methyl 3-(hydroxymethyl)aminocrotonate proceeds through a formal [3+3] process to yield the corresponding 1,2-dihydrobenzisoquinolinequinones in 63% and 72% yield, respectively. The reactions of 2-acyl-1,4-naphthoquinone with enaminones, derived from diverse l- and d-amino acid methyl esters, produced the corresponding naphthoq...

Diospyrin is a plant product that has significant inhibitory effect on the growth of Leishmania donovani promastigotes. This compound inhibits the catalytic activity of DNA topoisomerase I of the parasite. Like camptothecin, it induces topoisomerase I mediated DNA cleavage in vitro. Treatment of DNA with diospyrin before addition of topoisomerase I has no effect. Preincubation of topoisomerase ...

The immunomodulatory bioassay-guided fractionation of the methanolic extract of henna (Lawsonia inermis L.; syn. Lawsonia alba L.) leaves resulted in the isolation of seven compounds; three have been isolated for the first time from the genus, namely p-coumaric acid, 2-methoxy-3-methyl-1,4-naphthoquinone and apiin, along with the previously isolated compounds: lawsone, apigenin, luteolin, and c...

The synthesis and characterisation of three palladium complexes, involved in the homogeneous catalysis towards the CO-olefins coand ter-polymerisation reactions, are reported. The Pd (dpk·CH3OH) (CF3CO2)2 (1), (dpk = di(2-pyridyl) ketone) and Pd (dppp)(bipy) B(C6F5)4 2 (2), (bipy = 2,2’-bipyridine, dppp = 1,3-bis(diphenylphosphino)propane) compounds are examples of a neutral complex and of a di...