BACKGROUND This study was designed to investigate the impact of bispectral index (BIS) or A-line AAI index (based on middle-latency auditory evoked potential) monitoring on recovery times and drug consumption when compared with standard anaesthetic practice during desflurane-remifentanil anaesthesia. METHODS After having obtained approval from the institutional review board and written inform...

Introduction: Previous studies have suggested that Bispectral Index (BIS) may be less reliable in detecting depth of anesthesia or sedation during use of certain anesthetics or sedatives. These studies suggest that depth of sedation as measured by BIS may be drug-dependent. To date, data related to the effects of sedative agent on BIS in children are limited due to small sample sizes and inclus...

BACKGROUNDS AND OBJECTIVE Some studies have shown that deeper anesthesia is more effective on postoperative analgesia and reduces the need for sedative drugs. This study sought to investigate the effect of depth of anesthesia on postoperative pain in laparoscopic cholecystectomy. MATERIALS AND METHODS In this double-blind clinical trial, 60 patients undergoing laparoscopic cholecystectomy wer...

The ability of methylglyoxal-bis(guanylhydrazone) (MGBG) and 4,4'-diacetyldiphenylurea-bis(guanylhydrazone) to interact with the hypoglycémie agent, phenethylbiguanide (DBI), in affecting the bioenergetic functions of isolated rat liver mito chondria was studied. DBI was found to increase markedly the inhibitory effect of either 4,4'-diacetyldiphenylurea-bis(guanylhydrazone) or MGBG on respira...

BACKGROUND Dexmedetomidine is a useful sedative drug with various uses. We designed this study to investigate the clinical effects and complications of different loading doses, 0.5 and 1.0 µg/kg. METHODS Forty six patients, of American Society of Anesthesiologists physical status I and II, who required elective and emergency operation under spinal anesthesia were randomly assigned to group L ...

Bis(pivaloyloxymethyl) [bis(pom)] derivatives of various acyclic nucleoside phosphonates--9-(2-phosphonylmethoxyethyl)adenine (PMEA), 9-(2-phosphonylmethoxypropyl)adenine (PMPA), and 9-(2-phosphonylmethoxypropyl)diaminopurine (PMPDAP)--were found to exhibit 9- to 23-fold greater antiviral activity than their corresponding unmodified compounds. The cytotoxicity of the bis(pom) analogs was also i...

the reaction of bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (curcumin) and two novel ligands of bis[4-tetrabenzylglucose-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (bis(tetrabenzylglucose)curcumin) (btbgc) and bis[4-tetraacetylglucose-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (bis(tetraacetylglucose)curcumin) (btagc) with vanadium in methanol, in a 2:1 molar ratio, which yield the co...

Propylglyoxal bis(guanylhydrazone) sulfate, a novel analog of the well-known antileukemic drug methylglyoxal bis(guanylhydrazone), has been prepared from 2,2-dibromopentanal, and the compound has been characterized biochemically. Although it is a powerful inhibitor of S-adenosylmethionine decarboxylase, its Ki value (0.2 microM) is considerably higher than that of ethylglyoxal bis(guanylhydrazo...

Previous clinical trials and animal experiments have suggested that long-lasting exposure to general anaesthetics may lead to postoperative mental disturbance. Intraoperative monitoring of processed electroencephalogram (EEG), such as the bispectral index (BIS), has been shown to facilitate titration of anaesthetic drug delivery.1,2 The BIS monitor analyses raw EEG signals and displays a dimens...