نتایج جستجو برای: biopanning
تعداد نتایج: 251 فیلتر نتایج به سال:
We have developed a novel method, antagonistic template-based biopanning, for screening peptide ligands specifically recognizing local tertiary protein structures. We chose water-soluble pyrroloquinoline quinone (PQQ) glucose dehydrogenase (GDH-B) as a model enzyme for this screening. Two GDH-B mutants were constructed as antagonistic templates; these have some point mutations to induce disrupt...
Fish allergy is associated with moderate to severe IgE-mediated reactions to the calcium binding parvalbumins present in fish muscle. Allergy to multiple fish species is caused by parvalbumin-specific cross-reactive IgE recognizing conserved epitopes. In this study, we aimed to produce cross-reactive single chain variable fragment (scFv) antibodies for the detection of parvalbumins in fish extr...
High-grade epithelial ovarian cancer kills more women than any other gynecologic cancer and is rarely diagnosed at an early stage. We sought to identify tumor-associated antigens (TAA) as candidate diagnostic and/or immunotherapeutic targets by taking advantage of tumor autoantibody responses in individuals with ovarian cancer. Plasma-derived IgG from a pool of five patients with advanced ovari...
SARS-CoV-2 infects human cells by binding its spike protein to the ACE2 receptor. Using a peptide biopanning strategy, authors have discovered small anti-ACE2 peptides that can effectively block SARS-CoV-2/ACE2 interaction. The be potentially used as prophylactic or therapeutic agents for and other ACE2-mediated viruses. This is reported Kun Cheng co-workers in article number 2100087.
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