Sequential biomimetic elaborations, featured by CrO(3)-mediated oxidative lactonization, and DDQ-involved oxidative enol-lactonization, ensured the concise total synthesis of (+)-chloranthalactone F.

A detailed hypothesis for the biogenesis of haouamines is reported herein, supported by experiments headed towards biomimetic synthesis of these compounds.

A history of research projects undertaken in the group-ranging from mechanistic investigations to biomimetic chemistry to molecular devices and synthesis-is presented.

Recent studies have demonstrated that metal-organic frameworks can be employed as protective coatings for enzymes. Two efficient strategies have been reported for the synthesis of such composite materials: biomimetic mineralisation and controlled co-precipitation using polyvinylpyrrolidone. We assessed the relative efficacy of each approach by comparing the thermal stability of encapsulated ure...

The first total enantioselective synthesis of plakotenin is described. This marine natural product was isolated from an Okinawan sponge of the genus Plakortis and shows potent biological activity against several cancerous cell lines. A biomimetic intramolecular Diels-Alder reaction served as a key step in the total synthesis. The synthesis proves the relative and absolute stereochemistry of nat...

An enantioseletive, biomimetic synthesis of (-)-longithorone A has been achieved using an intermolecular/transannular Diels-Alder sequence which provides some support for the proposed biosynthesis. The cycloaddition precursors were two [12]-paracyclophanes that were constructed with atropisomer control during ene-yne metathesis macrocyclizations.

Enzymes are the core for biological transformations in nature. Their structures and functions have drawn enormous attention from biologists as well chemists since last century. The large demand of bioactive molecules pursuit efficiency greenness synthesis spurred rapid development biomimetic chemistry past several decades. Biomimetic asymmetric catalysis, mimicking enzymes, has been recognized ...