New genomic and proteomic technologies have led to important therapeutic advances in oncology. This article describes how the discovery of molecular prognostic markers to classify an individual patient’s risk of disease events and predictive markers to classify response to specific treatment options are used to guide the selection of treatment and identify targets for the development of new mol...

objective: antisocial, aggressive and delinquent behaviors in adults often begin early in life. basal cortisol is a valuable biological marker in children with disruptive behavior disorder (dbd). to investigate the association between biological factor (cortisol) and disruptive behaviors, we studied the effect of family training on salivary cortisol level in children with dbd. methods: basal sa...

between the nature of the brain damage in the aging process (in the case of dementia or even in outwardly healthy elderly people) and the brain damage caused by prion diseases of humans and animals (Sobel, 1970; Fraser and McBride, 1985; Masters et al., 1985; Gajdusek, 1988). In both cases, lesions are characterized by the two fundamental processes—the loss of neurons and an active proliferatio...

Concussions carry devastating potential for cognitive, neurologic, and socio-emotional disease, but no objective test reliably identifies a concussion and its severity. A variety of neurological insults compromise sound processing, particularly in complex listening environments that place high demands on brain processing. The frequency-following response captures the high computational demands ...

There is an enormous unmet need for biological markers to characterize disease type, status, progression, and response to therapy. We are developing and applying an integrated bioanalytical platform and clinical research program to facilitate comprehensive differential phenotyping of patient samples and enable the discovery of biomarkers. The platform employs high-throughput, quantitative analy...