OBJECTIVE Periodontal disease is considered to be a bio?film infectious disease. The effects of macrolide and tetracycline on biofilm were examined in in vitro biofilm model made of periodontal disease-associated bacteria. METHODS Biofilms were made on salivary pellicle by adding Streptococcus gordonii for 2 days, followed by Porphyromonas gingivalis inoculation for 2, 5, or 12 days. Biofilms...

Periodontal infections cause inflammatory destruction of the tooth supporting tissues. We recently developed a dynamic, in vitro periodontal organotypic tissue model in a perfusion bioreactor system, in co-culture with an 11-species subgingival biofilm, which may recapitulate early events during the establishment of periodontal infections. This study aimed to characterize the global proteome re...

Periodontitis is an immunoinflammatory disease that causes destruction of tooth supporting tissues. It is characterized by mulifactorial etiology involving bacterial biofilm and an inflammatory host response. The inflammatory ho destruction; thus novel therapeutic modalities should be considered that modulates host response. The proven efficacy of bisphosphonates to inhibit osteoclast bone reso...

Periodontitis is a polymicrobial infectious disease of multifactorial origin. Plaque biofilm associated host responses are involved in the pathogenesis of periodontitis. In periodontal diseases, bacteria trigger inflammatory host responses, which along with the direct destructive effects of the bacteria, cause most of the tissue destruction. Host modulation therapy aims to reduce tissue destruc...

Periodontal disease is a multifactorial disease associated with destruction of supporting periodontal tissues of the tooth caused by certain periodontopathogenic species of bacteria or their toxic products by means of a biofilm formation. The conventional methods to treat periodontal diseases are the mechanical removal of the biofilm and adjunctive use of antibacterial disinfectants or various ...

Periodontitis is an infectious disease that causes the inflammatory destruction of the tooth-supporting (periodontal) tissues, caused by polymicrobial biofilm communities growing on the tooth surface. Aggressive periodontitis is strongly associated with the presence of Aggregatibacter actinomycetemcomitans in the subgingival biofilms. Nevertheless, whether and how A. actinomycetemcomitans orche...

This paper discusses the role of dental biofilm and adjunctive therapies in the management of dental caries. Dental biofilm is a site of bacterial proliferation and growth, in addition to being a location of acid production. It also serves as a reservoir for calcium exchange between the tooth and saliva. The salivary pellicle, a protein-rich biofilm layer, regulates the reaction between tooth s...

Benzalkonium chloride (BAC) is a chlorine-based chemical compound with proven antimicrobial properties against bacteria, viruses, and fungi, depending on the length of alkyl chain. It can be used as biocide, cationic surfactant, phase transfer agent. The aim this study was to investigate effectiveness commercial cleaning agents for sanitary areas Bis duo Active (BDA) BAC an active in working co...

BACKGROUND The frequent occurrences of antibiotic-resistant biofilm forming pathogens have become global issue since various measures that had been taken to curb the situation led to failure. Euphorbia hirta, is a well-known ethnomedicinal plant of Malaysia with diverse biological activities. This plant has been used widely in traditional medicine for the treatment of gastrointestinal, bronchia...