Background/Aims: Common genetic variation at the IL28 locus has been found to affect the response of peg-interferon and ribavirin combination therapy against chronic hepatitis C virus (HCV) infection. An allele associated with a favorable response (rs8099917 T), which is the major allele in the majority of Asian, American and European populations, has also been found to be associated with spont...

The M200V polymorphism of the human DMC1 protein, which is an essential, meiosis-specific DNA recombinase, was found in an infertile patient, raising the question of whether this homozygous human DMC1-M200V polymorphism may cause infertility by affecting the function of the human DMC1 protein. In the present study, we determined the crystal structure of the human DMC1-M200V variant in the octam...

Genetic specificity occurs in many host-parasite systems. Each host can recognize and resist only a subset of parasites; each parasite can grow only on particular hosts. Biochemical recognition systems determine which matching host and parasite genotypes result in resistance or disease. Recognition systems are often associated with widespread genetic polymorphism in the host and parasite popula...

BACKGROUND The Trp64Arg polymorphism in the beta₃-adrenergic receptor (beta₃-AR) gene was extensively studied concerning the relationship with cardiovascular (CV) diseases, but few studies addressed this issue in athletes. AIM To examine the relationship between the Trp64Arg polymorphism in the beta₃-AR gene and several CV functions such as cardiac structure and function or blood biochemical ...

This article refers to viewing the role of molecular markers during analyzing genome plants and their importance in plant biotechnology. In recent years, we observed techniques programs for improving breeding preserving genetic resources has been observed, biochemical indicators which represent basic material through determining diversity between genotypes it is never affected by external surro...

Garlic belongs to the Allium genus, which includes more than 750 species divided into 60 taxonomic groups. It is cultivated in many countries throughout world for bulb and used as a spice functional food. The plant vegetatively propagates. This review will focus on origins, biology, analysis of genetic diversity, pharmacological properties garlic. appears from this synthesis that sativum derive...

Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and examined the association of the Val66Met B...