Intravesical instillation allows for direct exposure of the urothelium to a drug. However, therapeutic efficacy is often limited by rapid elimination drug from bladder. In this investigation, it hypothesized that morphology nanoparticulate delivery systems could significantly impact bioadhesion and bioelimination Bioadhesion kinetics evaluated ex vivo on rat bladder mucosa demonstrates particle...

We prepared hierarchically structured, superhydrophobic surfaces, with single-, dual-, and triple-scale roughness, via a layer-by-layer (LbL) particle deposition approach. The dual-/triple-scale structured, superhydrophobic surfaces exhibited significantly reduced protein adsorption (up to a 90% decrease). Furthermore, platelet adhesion and activation was completely suppressed on the triple-sca...

Bioadhesives In article 2203404 by Nasim Annabi, Ali Khademhosseini, and Paul S. Weiss co-workers, an efficient chemical route for mussel-inspired functionalization of natural biomacromolecules is developed to enhance sutureless sealing surgical wounds. Compared standard catechol functionalization, poly(catechol) modification gelatin leads injectable bioglues with rapid gelation hemorrhage cont...

The use of molecular biology tools in the field of bioadhesion is still in its infancy. For new research groups who are considering taking a molecular approach, the techniques presented here are essential to unravelling the sequence of a gene, its expression and its biological function. Here we provide an outline for addressing adhesion-related genes in diverse organisms. We show how to gradual...

In recent years, signiÞ cant interest has been shown in the development of novel bioadhesive dosage forms for mucosal delivery of drugs that attempt to overcome these limitations1. A bioadhesive dosage form necessitates the use of mucoadhesive polymers to adhere to mucosa and withstand salivation, tongue movement and swallowing for signiÞ cant period of time2. High molecular weight polymers are...