Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associated with animal studies. Negatively charged sialic acid residues are known to b...

Bioactive materials including glass and glass-ceramics are nowadays used as medical implants for orthopedic applications. In this study several samples of glass-ceramics have been prepared using both heat treatment and sol-gel processes. The structure and bioactivity of these samples based on their interaction with simulated body fluid (SBF) have been determined. In-vitor, using the Raman s...

CONTEXT The regulation of TSH bioactivity in humans is not completely understood. OBJECTIVE The aim of the study was to investigate the role of serum thyroid hormones in regulating the bioactivity of TSH. DESIGN We determined in vitro TSH bioactivity and glycosylation in nine patients (six females and three males, age 41.3 yr) with primary hypothyroidism before and after L-T(4) replacement,...

OBJECTIVE There is a complex relationship between IGF-I, IGF binding proteins, growth hormone, and insulin. The IGF-I kinase receptor activation assay (KIRA) is a novel method for measuring IGF-I bioactivity in human serum. We speculated that determination of IGF-I bioactivity might broaden our understanding of the IGF-I system in subjects with the metabolic syndrome. The purpose of our study w...

BACKGROUND Inadequate food intake plays an important role in the development of malnutrition in continuous ambulatory peritoneal dialysis (CAPD) patients. Aim of the study. The aim of the study was to investigate in CAPD patients whether circulating insulin-like growth factor-I (IGF-I) bioactivity may offer a more sensitive index to acute nutritional interventions than total IGF-I. METHODS An...

Bioactive glass (BG), a potential biomaterial, has received increasing attention since the discovery of its superior bioactivity. One of the main research objectives is to improve the bioactive property of BGs; therefore, surfactant-derived mesoporous bioactive glasses (MBGs) were developed to provide a high specific surface area for achieving higher bioactivity. In this study, various concentr...

We describe Scaffold Hunter, a highly interactive computer-based tool for navigation in chemical space that fosters intuitive recognition of complex structural relationships associated with bioactivity. The program reads compound structures and bioactivity data, generates compound scaffolds, correlates them in a hierarchical tree-like arrangement, and annotates them with bioactivity. Brachiatio...

The overall objective of this research is to enhance the bioactivity of cellulase enzymes as well as the stability of the enzymes to increase it reusability through immobilization of the enzymes in the microenvironment of porous inorganic-organic hybrid sol-gel polymers. Recently, we have discovered that the microenvironment of these sol-gel polymers markedly increases the bioactivity of immobi...

MOTIVATION Most of the previous data mining studies based on the NCI-60 dataset, due to its intrinsic cell-based nature, can hardly provide insights into the molecular targets for screened compounds. On the other hand, the abundant information of the compound-target associations in PubChem can offer extensive experimental evidence of molecular targets for tested compounds. Therefore, by taking ...