BACKGROUND/AIMS The long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear. The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with thiopurine in UC patients. METHODS This was a retrospective observational cohort analysis conducted at a single center. Between December 1998 an...

This study was performed to evaluate the potential costs of a hypothetical novel biological agent (BIO) as a therapy for rheumatoid arthritis (RA), compared with oral methotrexate (MTX) and intramuscular gold (IMG). A decision analysis model was used to compare the total costs of treating a cohort of 10,000 RA patients with each agent for 6 months. Total costs included direct costs and indirect...

there was a turning point in each period of time which human has discovered a new sight about the world and nature order in a way, and then has presented this relation by numeral, artful and industrial language. biourbanism focuses on the urban organism, considering it as a hyper complex system, according to its internal and external dynamics and their mutual interactions. nowadays when it is t...

OBJECTIVES Anemia is a common complication among chronic kidney disease patients on hemodialysis, occurring mostly due to erythropoietin deficiency. This randomized noninferiority trial sought to compare the efficacy and safety of a new epoetin formulation developed by Bio-Manguinhos, a biologics manufacturer affiliated with the Brazilian government, with those of a commercially available produ...

Ahmad K. (2014): Molecular farming: strategies, expression systems and bio-safety considerations. Czech J. Genet. Plant Breed., 50: 1–10. Molecular farming is an experimental application of biotechnology that involves the genetic modification of crops for the production of proteins and chemicals for medicinal and commercial purposes. The vast majority in the developing world cannot afford the h...

Objectives of the Doctoral Program Structural, Seismic and Geotechnical Engineering SSGE consists of the disciplines and techniques that allow to understand, model and control the behavior of: (a) structural materials (concrete, steel, masonry, composites, bio-materials and materials for micro-systems), (b) structural systems (from constructions to bio-mechanical systems and micro-systems), (c)...

In this paper, we propose a simple and relative electrode contact monitoring method. By exploiting the power line interference, which is regarded as one of the worst noise sources for bio-potential measurement, the relative difference in electrode impedance can be measured without a current or voltage source. Substantial benefits, including no extra circuit components, no degradation of the bod...

Surface plasmon resonance (SPR) imaging sensors realize label free, real-time, highly sensitive, quantitative, high throughput biological interaction monitoring and the binding profiles from multi-analytes further provide the binding kinetic parameters between different bio-molecules. In the past two decades, SPR imaging sensors found rapid increasing applications in fundamental biological stud...