introduction: intracellular ph (phi) regulates essentially all aspects of cellular activities. however, it is unknown how endoplasmic reticulum (er) potassium channels sense phi. in this study, we investigate the direct effects of phi on er potassium channels. methods: we used channel incorporation into the bilayer lipid membrane method. l-α-phosphatidylcholine, a membrane lipid, was extracted ...

To think quantitatively about comovement, we specify the model of Section I. We use a CES production function for one final good. 42 Thus, we can solve the structure of this economy in closed form, and quantify its comovement. Our model differs in a series of small ways from 43 Its main virtue is that it is solvable in closed form, so that the mechanisms are fairly transparent.

Hypertension is a leading risk factor for the development of cardiovascular disease. Data from human and animal studies suggest that RGS2, a potent inhibitor of G(q) signaling, is important for blood pressure regulation. Several RGS2 mutations in the Japanese population have been found to be associated with hypertension. The product of one of these alleles, R44H, is mutated within the amino ter...

I describe two studies that were designed to illustrate the potential applicability of laboratory-derived ESP effects in trying to predict events of practical consequence in the “real world.” Both studies attempt to predict the behavior of sets of fi nancial indices over a designated week in the future. The studies followed up on earlier work on the prediction of scoring direction and scoring e...

Th is paper investigates the role of information technology in fi nancial reporting as well as the relationship between using information technology and its impact on the quality of fi nancial reporting. To identify the impact of information technology on quality of fi nancial reporting, a questionnaire was designed and developed. In order to test the hypotheses, T-Test, ANOVA and Duncan’s Test...

The level 1 highest weight modules of the quantum affine algebra Uq(ŝln) can be described as spaces of certain semi-infinite wedges. Using a q-antisymmetrization procedure, these semi-infinite wedges can be realized inside an infinite tensor product of evaluation modules. This realization gives rise to simple descriptions of vertex operators and (up to a scalar function) their compositions. 1 R...

This study aimed to explore non-verbal executive processes in simultaneous interpreters. Simultaneous interpreters, bilinguals without any training in simultaneous interpreting, and control monolinguals performed the Wisconsin card sorting task (WCST; Experiment 1) and the Simon task (Experiment 2). Performance on WCST was thought to index cognitive flexibility while Simon task performance was ...

Liposomal drug carriers are nano-scale, spherical particles with a phospholipid bilayer surrounding an aqueous core and are commonly used for chemotherapeutic delivery. Chemotherapy efficacy is limited by toxicity and tumor drug resistance; however, with increased circulation and improved tumor deposition due to the enhanced permeability and retention effect, liposomes increase treatment effica...