BACKGROUND AND AIMS Administration of omeprazole to healthy volunteers was recently reported to increase proximal duodenal mucosal bicarbonate secretion. As human oesophagus also secretes bicarbonate, the hypothesis was tested that omeprazole may stimulate oesophageal bicarbonate secretion and thus contribute to the therapeutic efficacy of the drug in gastro-oesophageal reflux disease. SUBJEC...

In the pathogenic bacterium Bacillus anthracis, virulence requires induced expression of the anthrax toxin and capsule genes. Elevated CO2/bicarbonate levels, an indicator of the host environment, provide a signal ex vivo to increase expression of virulence factors, but the mechanism underlying induction and its relevance in vivo are unknown. We identified a previously uncharacterized ABC trans...

We previously reported that rabbit renal cortical collecting tubules can secrete bicarbonate in vitro (i.e., there can be net transport from bath to lumen, causing the concentration in the lumen to increase). Net bicarbonate secretion was observed most often when rabbits had been pretreated with NaHCO(3) and were excreting alkaline urine before being killed for experiments. The purpose of the p...

Sodium fluxes across the isolated rabbit corneal endothelium were measured as a function of ambient pH and bicarbonate concentrations. At pH 7, the net sodium flux (J endo str net) was effectively obliterated at all bicarbonate concentrations, relative to controls at pH 7.5. At pH 8, the net sodium flux was obliterated at 5 mM bicarbonate, was unchanged at 25 mM bicarbonate, and was enhanced at...

BACKGROUND Sodium bicarbonate is despite its side effects, considered the standard alkali therapy in metabolic acidosis. THAM is an alternative alkalizing agent; however, there are limited data on the use of THAM in metabolic acidosis. The aim of this study was to compare the efficacy and adverse effects of a single dose of sodium bicarbonate and THAM in intensive care unit (ICU) patients with ...

BACKGROUND Some nephrologists have advocated an individualized approach to the prescription of bicarbonate hemodialysis. However, the utility of monthly serum bicarbonate levels for guiding and evaluating such treatment decisions has not been evaluated. We sought to define the variability of these measurements and to determine factors that are associated with month-to-month variability in pre-d...

KARLINSKY,MALCOLM L., DAVID S. SAGER,NEIL A. KURTZMAN, AND V. K. G. PILLAY. Efect of parathormona and cych adenosine monophosphate on wnal bicarbonate reabsorption. Am. J. Physiol. 227(6): 12264231. 1974.-Several recent studies have suggested that parathyroid hormone directly depresses renal bicarbonate reabsorptionTo test this thesis, we infused highly purified parathyroid hormone (PTH) and di...

BACKGROUND Topiramate has been associated with metabolic acidosis secondary to decreased serum bicarbonate. Product labeling recommends serum bicarbonate monitoring at baseline and periodically thereafter. OBJECTIVE The study objective was to assess changes in serum bicarbonate within the first year of topiramate use in an outpatient veteran population. METHODS This was a single-center, ret...

1. Bicarbonate increased citrate and 2-oxoglutarate accumulation when rat kidney cortex mitochondria were incubated with pyruvate or L(-)-palmitoyl carnitine in the presence of L-malate. 2. Bicarbonate stimulated the exit of citrate from mitochondria. The Km for bicarbonate was 13.5 mM and the Vmax was 0.59 nmol/min/mg of protein at 10 degrees. 3. The bicarbonate-stimulated exit of citrate from...

Sodium-bicarbonate cotransporters are homologous membrane proteins mediating the electrogenic or electroneutral transport of sodium and bicarbonate. Of the functionally characterized sodium-bicarbonate cotransporters (NBC), NBC1 proteins are known to be electrogenic. Here we report the cloning and functional characterization of NBC4c, a new splice variant of the NBC4 gene. At the amino acid lev...