BACKGROUND There is an urgent need to measure phosphorylated cell signaling proteins in cancer tissue for the individualization of molecular targeted kinase inhibitor therapy. However, phosphoproteins fluctuate rapidly following tissue procurement. Snap-freezing preserves phosphoproteins, but is unavailable in most clinics and compromises diagnostic morphology. Formalin fixation preserves tissu...

6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available. For the nudibranch mollusk Hermissenda crassicornis no endogenous compounds were known, and here we describe the isolation of 6-BHP from this mollusk and its effects on different nicotinic acetylchol...

The present study was performed to investigate the effect of 5-bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one (BHP) on the induction of apoptosis and cell cycle arrest in T24 human bladder carcinoma cells. An MTT assay was used to investigate the inhibition of cell proliferation. Flow cytometry was used to observe alterations in the cell cycle, generation of reactive oxygen species (ROS), altera...

In recent works [1] (BHP), a generalized universality has been proposed, linking phenomena as dissimilar as 2D magnetism and turbulence. To test these ideas, we performed a MC study of the 2DXY-model. We found that the shape of the probability distribution function for the magnetization M is non Gaussian and independent of the system size, below the Kosterlitz-Thoules temperature. However, the ...

In this paper we have studied the failures in medical electrodes such as electroencephalogram electrodes (EEG) being used for collecting brain signals. As those electrodes have to guarantee high level of reliability it is important to explore and predict the possible occurrence of failures in there structure. The electrode tip (needle) made of stainless steel is covered with thin oxide film act...

This paper presents an application of computer The implementation and operation of the system is vision in a real-world uncontrolled environment found at BHP Steel Port Kembla. The task is visual identification of torpedo ladles at a Blast Furnace wlahdilceh. is achieved by reading numbers attached to each 3. IMPLEMENTATION Number recognition is achieved through use of feature extraction using ...

Rats and hamsters were administered a single dose of N-[1-14C]nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), and their urinary metabolites were examined at various time intervals. In both species, urinary excretion of radiolabeled metabolites reached a plateau at 6 h following injection. At this time, 35 and 28% of the total dose was found in the urine of rats and hamsters, respectively. Se...