Abstract Heat stress has multiple potential effects on the brain, such as neuroinflammation, neurogenesis defects, and cognitive impairment. β-hydroxybutyric acid (BHBA) been demonstrated to play neuroprotective roles in various models of neurological diseases. In present study, we investigated efficacy BHBA alleviating heat stress-induced impairments adult hippocampal function, well underlying...

BACKGROUND Hydroxy-carboxylic acid receptor 2 (HCA2, also called GPR109A) belongs to the G protein-coupled receptor (GPCR) family and is found in humans, rats, mice, hamsters and guinea pigs, but there are almost no reports of this protein in other species. In this investigation, we speculated that AMP010014A09 (AMP+) is a homologue of GPR109A in swine. METHODS To test this hypothesis, the fo...

Ketosis is a common metabolic disorder frequently observed in dairy cows during the early lactation period. The objective of this study was to examine the changes in β-hydroxybutyrate (BHBA), glucose, non-esterified fatty acids (NEFA), glutathion peroxidase (GSH-Px), superoxide dismutase (SOD), xanthine oxidase (XOD), malonaldehyde, catalase and total antioxidant capacity (T-AOC) concentrations...

Negative energy balance and ketosis are thought to cause impaired immune function and to increase the risk of clinical mastitis in dairy cows. The present in vitro study aimed to investigate the effect of elevated levels of the predominant ketone body β-hydroxybutyrate on the innate defense capability of primary bovine mammary epithelial cells (pbMEC) challenged with the mastitis pathogen Esche...

Metabolic adaptations during negative energy and nutrient balance in dairy cows are thought to cause impaired immune function and hence increased risk of infectious diseases, including mastitis. Characteristic adaptations mostly occurring in early lactation are an elevation of plasma ketone bodies and free fatty acids (nonesterified fatty acids, NEFA) and diminished glucose concentration. The a...

This study was conducted to estimate the genetic parameters of β-hydroxybutyrate (BHBA) and acetone concentration in milk by Fourier transform infrared spectroscopy along with test-day milk production traits including fat %, protein % and milk yield based on monthly samples of milk obtained as part of a routine milk recording program in Korea. Additionally, the feasibility of using such data in...

The adaptive response to a given metabolic load during energy deficiencies varies considerably among animals. The aim of this study was to investigate if individual cows respond in a repeated manner to a negative energy balance (NEB) in early and mid-lactation. Twenty-five multiparous Holstein dairy cows (3.0 ± 1.1 parities; mean ± SD) experienced a NEB during the first weeks of lactation, and ...

The objectives of this study were to describe the incidence of postpartum disease and to evaluate the association with serum cholesterol concentrations during the first 3 weeks after calving in grazing dairy cows. The association between non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHBA), calcium and postpartum diseases was also evaluated. A total of 307 Holstein dairy cows from 6 comm...

The study was conducted to compare the haematological, biochemical and nutritional parameters between healthy foals (HF) weak (WF, malformation, lameness drooping ears), corresponding female donkeys provide a reference for assessment of status. A total 34 with HF (DHF) WF (DWF) were selected. Compared HF, had higher leukocyte, neutrophil, platelets (PLT) percentage their showed similar tendency...