DNA microarray analyses were used to investigate the effect of cell-incorporated 35S-methionine on human colorectal carcinoma cells. This beta-radiation-induced gene expression profile was compared with that induced by external gamma-radiation. The extent of DNA fragmentation was used as a biomarker to determine the external gamma dose that was bioequivalent to that received by cells incubated ...

NHL is the most common hematologic cancer in adults. Rituximab is the FDA approved treatment of relapsed or refractory low grade B-cell Non-Hodgkin Lymphoma (NHL). But patients eventually become resistant to rituximab. Since lymphocytes and lymphoma cells are highly radiosensitive, low grade NHL that has relapsed or refractory to standard therapy is treated by RIT in which a beta-emitting radio...

NHL is the most common hematologic cancer in adults. Rituximab is the FDA approved treatment of relapsed or refractory low grade B-cell Non-Hodgkin Lymphoma (NHL). But patients eventually become resistant to rituximab. Since lymphocytes and lymphoma cells are highly radiosensitive, low grade NHL that has relapsed or refractory to standard therapy is treated by RIT in which a beta-emitting radio...

UV irradiation has been shown to activate the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in cell culture; however, only limited studies have been described in vivo. UV light has been categorized as UV-A (400 to 315 nm), -B (315 to 280 nm), or -C (less than 280 nm); the longer wavelengths are less harmful but more penetrative. Highly penetrative UV-A radiation constit...

Secondary beam course and its irradiation system have been constructed in HIMAC. In this system, positron emitter beam can be used to measure the irradiated volume with PET. As an irradiation method to use beam efficiently, the spot scanning irradiation was adopted. With this spot scanning system, irradiation test has been done with C beam. In this paper, the current status of the beam control ...

introduction:the use of beta emitters is one of the effective methods for palliation of bone metastasis. the risk of normal tissue toxicity should be evaluated in the bone pain palliation treatment. methods: in this study, the monte carlo simulation code mcnpx was used for simulation a bone phantom model consisted of bone marrow, bone and soft tissue. specific absorbed fractions were calculated...

The stand-alone microbeam, under development at RARAF, presents a novel approach to biological microbeam irradiation studies. Foregoing a conventional accelerator as a source of energetic ions, we propose to use a small, high-specific-activity, alpha emitter. Alpha particles emitted from this source are focused using a compound magnetic lens consisting of 24 permanent magnets arranged in two qu...

A laboratory soil column experiment was first conducted to analyze water movement in latosol of sugarcane field under drip irrigation from single-point source at different emitter discharge rates. Next, a mathematical model of soil water movement under drip irrigation from single-point source was built using Hydrus-3D, which could accurately simulate the shape of the wetted soil volume and the ...