UNLABELLED Ex vivo autoradiographs of healthy kidney tissue from patients who received (111)In-DTPA-octreotide (DTPA is diethylenetriaminepentaacetic acid) before nephrectomy showed very heterogeneous radioactivity patterns in the kidneys. The consequences of the reported inhomogeneities have been evaluated for radionuclide therapy with (90)Y- DOTA-Tyr(3)-octreotide (DOTA is 1,4,7,10-tetraazacy...

Introduction:Targeted radionuclide therapy (TRT) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. TRT is generally performed with a single radionuclide. In this study we investigated the feasibility of combined TRT with a high-energy beta emitter (153Sm) and a low energy beta emitter (177Lu) in wistar...

Abstract Background For radiopharmaceuticals, aseptic preparation in combination with filtration is the most commonly used sterilizing method. In general, production of radiopharmaceuticals needs to fulfil requirements good manufacturing practice. scope this work, we focused on positron emitter gallium-68 and therapeutically beta- gamma-emitter lutetium-177, as they are routinely for in-house s...

BACKGROUND In the porcine overstretch injury model of restenosis, endovascular beta-radiation reduces neointima formation. To determine whether this therapy could be applied to patients with coronary artery disease, a special device was developed to allow delivery of 12 encapsulated 90Sr/Y sources, measuring a total of 30 mm, to various sites within the coronary arterial tree. This study was de...

This paper describes an investigation of the performance compromises imposed by a manufacturing approach that utilizes lithographic micromachining processes to fabricate a wireless beta/gamma radiation detector. The device uses in-package assembly of stainless steel electrodes and glass spacers. These elements are micromachined using photochemical etching and powder blasting, respectively. The ...

Radionuclides existing in the environment, both natural and artificial, are accumulated in plants and animals and transferred through the trophic chain. That is the way which more and more wakes up to the interest of longterm impact on living organisms and the possibility of their transfer through feed way to human body. Basing on their high radiotoxicity to living organisms the alpha emitting ...

Introduction: The dosimetric characteristics of patch sources including 32P, 90Y, 188Re and 166Ho, which are employed for radionuclide skin therapy, have been evaluated in current study Materials and Methods: The patch sources understudy were modeled by MCNPX Monte Carlo code and corresponding depth dose distribution, transverse dose profile and isodose curves...

When attacked by insects, plants release mixtures of volatile compounds that are beneficial for direct or indirect defense. Natural variation of volatile emissions frequently occurs between and within plant species, but knowledge of the underlying molecular mechanisms is limited. We investigated intraspecific differences of volatile emissions induced from rosette leaves of 27 accessions of Arab...