Background: Ovarian neoplasms are the second most common cause of gynecological malignancy both worldwide as well in India. Innocuous clinical presentation and late diagnosis contribute to mortality toll this neoplasm. Thus, early remains cornerstone increase survival rate ovarian neoplasms. Though, cancer antigen 125 (CA-125) is a time-tested marker for neoplasm yet its increment benign condit...

In this issue, Koo and colleagues authored an interesting article entitled “An 11-year experience with ovarian surgery during pregnancy”. They investigated the characteristics and outcomes of pregnant women who underwent surgical intervention for ovarian neoplasm and found that either conventional laparotomy or laparoscopy approach could be successfully used in the management of ovarian tumor d...

Four patients are described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. It is possible that the initial thyroid neoplasm was a well- differentiated follicular carcinoma which was microscopically indistinguishable from a benign adenoma. Realizing this pathologic pitfall in thyroid diagnosis, the need for meticulous examination of the pa...

Sclerosing stromal tumor (SST) was first delineated as a distinct ovarian sex cord stromal tumor in 1973 by Chalvardjian and Scully. It is a benign neoplasm, distinguished from other ovarian stromal tumors by the production of collagen and a pseudolobular pattern, and it tends to occur in the second and third decades of life in diagnosed patients. We discovered two rare cases of SST in post-men...

BACKGROUND AND PURPOSE Maspin is an inhibitor of serine proteinases with tumor suppressor activity that is down-regulated in breast and prostate cancer, but overexpressed in pancreatic carcinoma. However, there were very few published data regarding the role of maspin in ovarian carcinoma. The aim of the present study was to evaluate maspin expression in ovarian epithelial neoplasms and correla...

OBJECTIVE To study the clinical and histological nature of benign adnexal masses managed surgically. METHODS A retrospective descriptive study in a teaching hospital in Oman of all the women who had surgical management of benign adnexal masses from January 2008 to May 2012. Data pertaining to age, parity, presenting symptoms, imaging and tumor markers performed and the surgical intervention d...

PURPOSE Jab1 (Jun activation domain-binding protein 1) has been described as a coactivtor of AP1 transcription factor, and is a subunit of a large protein complex (called the COP9 signalosome). Recent study (K. Tomoda et al., Nature (Lond.), 398: 160-165, 1999) found that Jab1 protein can cause breakdown of p27(kip1) protein in mammalian cells. To investigate whether Jab1 expression is correlat...

Brenner tumor is a relatively uncommon neoplasm. It constitutes 1.4–2.5 % of all ovarian tumors and has a predilection for the postmenopausal women. Most Brenner tumors are benign, with only 2–5 % being malignant. The malignant components of the tumor, which show heterogeneous epithelial growth and atypia with intervening stroma, consist of transitional cells, squamous or undifferentiated carci...