Abstract Background Bear bile powder is a precious natural material characterized by high content of tauroursodeoxycholic acid (TUDCA) at ratio 1.00–1.50 to taurochenodeoxycholic (TCDCA). Results In this study, we use the crude enzymes from engineered Saccharomyces cerevisiae directionally convert TCDCA chicken TUDCA committed in vitro. This S. strain was modified with heterologous 7α-hydroxyst...

Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [PubChem] Indication: The drug reduces cholesterol absorption and is used to dis...