نتایج جستجو برای: bcg and salmonella infection

تعداد نتایج: 16924755  

Journal: :Infection and immunity 1973
J S Youngner S B Salvin

When mice infected with Mycobacterium tuberculosis strain BCG were inoculated intravenously with old tuberculin (OT) or living BCG cells, both migration inhibitory factor (MIF) and interferon appeared in the circulation within a few hours. In such animals, which showed delayed hypersensitivity by footpad tests, as little as 1.5 mg of OT or as few as 1.7 x 10(6) bacteria per mouse were capable o...

Journal: :Antimicrobial agents and chemotherapy 2001
J Moisan W Wojciechowski C Guilbault C Lachance S Di Marco E Skamene G Matlashewski D Radzioch

The mouse bcg host resistance gene is known to control the activation of host macrophages for killing of intracellular parasites like Leishmania donovani as well as intracellular bacteria, including Mycobacterium bovis BCG and Salmonella enterica serovar Typhimurium. The Nramp1 gene has been mapped to this locus and affects the efficiency of macrophage activation. It has been shown that imidazo...

Objective(s): Infection with tuberculosis (TB) is regarded as a major health issue. Due to the emergence of antibiotic resistance during TB treatment, prevention via vaccination is one of the most effective ways of controlling the infection. DNA vaccines are developed at a greater pace due to their ability in generating a long-lasting immune response, higher safety com...

2018
Stephanie A. Harris Andrew White Lisa Stockdale Rachel Tanner Laura Sibley Charlotte Sarfas Joel Meyer Jonathan Peter Matthew K. O'Shea Zita-Rose Manjaly Thomas Ali Hamidi Iman Satti Mike J. Dennis Helen McShane Sally Sharpe

The lack of validated immunological correlates of protection makes tuberculosis vaccine development difficult and expensive. Using intradermal bacille Calmette-Guréin (BCG) as a surrogate for aerosol Mycobacterium tuberculosis (M.tb) in a controlled human infection model could facilitate vaccine development, but such a model requires preclinical validation. Non-human primates (NHPs) may provide...

A. S. Srujana D. S. Akhila, J. Sonalika K. S. Santhosh M. R. Juliet

Background: Salmonella, a bacterial genus of more than 2500 serotypes is considered as the most significant foodborne pathogen causing infections in humans and animals. Increased antimicrobial resistance and persistence of antimicrobial residues in food matrices warrants the need for alternative infection management strategies. Aims: The present study aimed to isolate and evaluate the lytic act...

2011
Bo-Young Jeon Hyungjin Eoh Sang-Jun Ha Hyeeun Bang Seung-Cheol Kim Young-Chul Sung Sang-Nae Cho

PURPOSE Bacillus Calmette-Guérin (BCG) vaccine has widely been used to immunize against tuberculosis, but its protective efficacy is variable in adult pulmonary tuberculosis, while it is not efficiently protective against progressive infection of virulent Mycobacterium tuberculosis strains. In this study, the protective effects of plasmid DNA vaccine constructs encoding IL-12 or IL-18 with the ...

پایان نامه :وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی و خدمات بهداشتی درمانی استان فارس - دانشکده دندانپزشکی 1380

چکیده ندارد.

Journal: :cell journal 0

introduction: study the protective effect of mucosal bcg vaccination with subcutaneous against leishmania major infection in susceptible balb/c mice material and methods: 6-8 weeks old male balb/c mice,were divided to two test groups and four control groups of 20 of mice and then vaccinated. two test groups vaccinated with appropriate dose of bcg through rectal and subcutaneous routs. they vacc...

Background: Although the efficacy of Bacillus Calmette-Guerin (BCG) vaccine in the prevention of tuberculosis has been noted consistently, the use of BCG vaccine is not without risk. In this study we aimed to evaluate immunologically, children with complication of BCG vaccination in North of Iran.Materials and Methods: This case-control study began in 30 Jan 2013 and was completed in 2 Jul 2015...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 1999
A P Ferreira F M Aarestrup M G Bonecini-Almeida E E Souza E A Gomes J O Corrêa H C Teixeira

Injection of an Ascaris suum extract (Asc) affects both the humoral and cellular immune responses to unrelated antigens when it is co-administered with these antigens. In the present study we evaluated the effect of Asc on macrophage activation in the early phase of Mycobacterium bovis BCG (Pasteur strain TMCC 1173) infection in C57Bl/6 mice. C57Bl/6 mice were injected intraperitoneally (ip) wi...

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