نتایج جستجو برای: bax gene
تعداد نتایج: 1149573 فیلتر نتایج به سال:
Introduction: This study aimed to compare the response of liver tissue BAX and BCL-2 gene expression to aerobic training with L-carnitine supplementation in rats intoxicated by Boldenone. Material and Methods: In this experimental study, 30 male Wistar rats, aged 12 weeks (weight 195±7.94 g) were randomly divided into five groups: control, no-treatment, boldenone (5 mg/kg), L-carnitine (100 mg...
Background & aim: In Iran, cervical cancer is the second leading cause of death in women. Papillomavirus infection is the most important risk factor for the development of cervical cancer. Ca SKi cell is a human cervical carcinoma cell that binds the papillomavirus type 16 virus to its genome. Cactin is a type of phenol and a secondary metabolite of a plant. The purpose of this study was to inv...
Background & Aims: Plant extracts can change the expression of genes in cancer cells. Till now, no study has been performed on the effect of algae extract. The aim of this research was to study the changes in Bax apoptotic gene expression in glioblastoma cell line and to determine the rate of cell death in cancer cells treated with Dunalilla salina extract. U87 cell line contains glioblas...
objective: curcumin, is the active component in turmeric (curcuma long). this agent induces apoptosis via inhibiting various signaling pathways. however, its poor aqueous solubility prevents its widespread application. in this study, dendrosomes with water-solubility, nano-sized dimensions and nontoxic properties, was used for curcumin delivery to cells. materials & methods: in the present...
BACKGROUND Bax is a strong pro-apoptotic gene that induces programmed cell death when expressed. Human telomerase reverse transcriptase (hTERT) is the catalytic subunit for telomerase, an enzyme found to be active in more than 85% of human cancers. Recently, a binary adenoviral system (Ad/GT-Bax + Ad/hTERT-GV16) was constructed using the hTERT promoter to induce Bax gene expression in tumor cel...
Introduction: Cancer can be defined as an illness of reformed gene expression. There are numerous agents affecting expression and altering cellular activities. Nanotechnology has offered the possibility modulating tumor suppressor genes’ expression, improving kinetics gene-targeted therapeutics, simplifying drug delivery to tumors across bio-complexes.Methods: Gene expressions caspase3, 8 9, Ba...
Background: One of the most growing diseases is the onset of atherosclerosis which can be started from a fetal age. As a result, the intrauterine environment plays a role at risk of spreading this disease. Changes in vascular function considered to be as an indicator for vascular disease. Effective factors on vascular function are enzyme eNOS and apoptotic regulator factors included BCL-2 an...
Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was deter...
The bax gene promoter region contains four motifs with homology to consensus p53-binding sites. In cotransfection assays using p53-deficient tumor cell lines, wild-type but not mutant p53 expression plasmids transactivated a reporter gene plasmid that utilized the bax gene promoter to drive transcription of chloramphenicol acetyltransferase. In addition, wild-type p53 transactivated reporter ge...
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