Mammalian cell culture technology has improved so rapidly over the last few years that it is now commonplace to produce multi-kilogram quantities of therapeutic monoclonal antibodies in a single batch. Purification processes need to be scaled-up to match the improved upstream productivity. In this chapter key practical issues and approaches to the scale-up of monoclonal antibody purification pr...

The classical multi-level capacitated lot-sizing problem is often not suitable to correctly capture resource requirements and precedence relations. We tackle this issue by explicitly modeling these two aspects. Two models are presented; one considering batch production and the other one allowing lot-streaming. Comparisons with traditional models demonstrate the capability of the new approach to...

One of the fundamental problems in operations management is to determine the optimal investment in capacity. Capacity investment consumes resources and the decision is often irreversible. Moreover, the available capacity level affects the action space for production and inventory planning decisions directly. In this paper, we address the joint capacitated lot sizing and capacity acquisition pro...

This paper describes our submission to the WMT 2017 Neural MT Training Task. We modified the provided NMT system in order to allow for interrupting and continuing the training of models. This allowed mid-training batch size decrementation and incrementation at variable rates. In addition to the models with variable batch size, we tried different setups with pre-trained word2vec embeddings. Asid...

This paper formally defines the Ratio Modeling technique as set of steps enabling you to quickly perform low confidence capacity predictions, which are required when budgeting hardware, assessing technical risk, validating alternative technical architecture designs, sizing packaged applications, and predicting production system capacity requirements. This technique enables you to define the rel...

An extended economic production quantity (EPQ) model under stochastic demand is investigated in this paper, where a fixed lot sizing policy is implemented to reduce the complexity of production planning and inventory control, and outsourcing with a secondary facility is used to supplement the lot sizing policy and to cope with the random demand. The considered cost includes: setup cost for the ...

The strategies employed in chromatography steps play a key role in downstream processes for monoclonal antibody (mAb) manufacture. This work addresses the integrated optimisation of chromatography step sequencing and column sizing in mAb purification processes. Chromatography sequencing decisions include the resin selection at each typical step, while the column sizing decisions include the num...

In spite of the remarkable improvements in the quality of general purpose mixed-integer programming software, the effective solution of a variety of lot-sizing problems depends crucially on the development of tight formulations for the special problem features occurring in practice. After reviewing some of the basic preprocessing techniques for handling safety stocks and multilevel problems, we...