The present work was aimed to develop and characterize rosuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia (RSEDDS) for improving bioavailability, to enhance solubility, to prolong residence time and to provide sufficient amount of drug to a target site in a sustained release manner. Self-emulsifying drug delivery system was prepared by simple...

This paper considers the uncapacitated lot sizing problem with batch delivery, focusing on the general case of timedependent batch sizes. We study the complexity of the problem, depending on the other cost parameters, namely the setup cost, the fixed cost per batch, the unit procurement cost and the unit holding cost. We establish that if any one of the cost parameters is allowed to be time-dep...

In this study, a distributed flow shop scheduling problem with batch delivery constraints is investigated. The objective to minimize the makespan and energy consumptions simultaneously. To end, hybrid algorithm combining wale optimization (WOA) local search heuristics developed. proposed algorithm, each solution represented by three vectors, namely job sequence vector, assignment factory vector...

This paper deals with a single-machine scheduling problem in which jobs are released in different points in time but delivered to customers in batches. A due window is associated with each job. The objective is to schedule the jobs, to form them into batches and to decide the delivery date of each batch so as to minimize the sum of earliness, tardiness, holding, and delivery costs. A mathematic...

The growth in demand for semiconductors has been accompanied by intense competition between semiconductor manufacturers to satisfy customer on-time delivery needs. This paper is motivated by scheduling the wafer fabrication phase of 300-mm semiconductor manufacturing, as it contains both batch processing operations and multiple customer orders being grouped into production jobs. The resulting m...

Scheduling is a key factor for manufacturing productivity. Effective scheduling can improve on-time delivery, reduce work-in-process inventory, cut lead time, and improve machine utilization. Motivated by the extensive use of batch machines in manufacturing industries, the scheduling of job shops with batch machines is studied in this paper. Unlike machines that can process one part at a time (...

The secretion of melatonin (MT) is obviously different in the younger and the senior sectors of the population, and the maximum plasma concentration of seniors is only half of that in the younger population group. If exogenous MT can be supplied to senior citizens based on the secretion rate and amount of endogenous MT in the younger population by a bio-mimetic drug delivery system (DDS), an im...