نتایج جستجو برای: barnes maze

تعداد نتایج: 13229  

2017
Katherine Houlé Myshake Abdi Erin B D Clabough

OBJECTIVE Prenatal alcohol exposure can result in neurological changes in affected individuals and may result in the emergence of a broad spectrum of neurobehavioral abnormalities termed fetal alcohol spectrum disorders (FASD). The effects of ethanol exposure during development are both time and dose dependent. Although many animal models of FASD use more chronic ethanol exposure, acute develop...

2014
Ivar S. Stein Michaela S. Donaldson Johannes W. Hell Karl-Ulrich Bayer Mark L. Dell’Acqua

Learning and memory as well as long-term potentiation (LTP) depend on Ca (2+) influx through the NMDA-type glutamate receptor (NMDAR) and the resulting activation of the Ca (2+) and calmodulin-dependent protein kinase (CaMKII). Ca (2+) influx via the NMDAR triggers CaMKII binding to the NMDAR for enhanced CaMKII accumulation at post-synaptic sites that experience heightened activity as occurrin...

2017
Devin Wahl Sean CP Coogan Samantha M Solon-Biet Rafael de Cabo James B Haran David Raubenheimer Victoria C Cogger Mark P Mattson Stephen J Simpson David G Le Couteur

Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recogni...

Journal: :Hormones and behavior 2004
Timothy W Bredy Anna W Lee Michael J Meaney Richard E Brown

In the laboratory rat and mouse, neonatal handling enhances hippocampal-dependent learning in adulthood, an effect mediated by changes in maternal behavior toward the handled young. In the present study, we examined the interaction between neonatal handling and biparental care during the early postnatal period and its effect on cognitive function in adult California mice (Peromyscus californicu...

Journal: :Anesthesiology 2014
Junfeng Zhang Hongying Tan Wei Jiang Zhiyi Zuo

BACKGROUND Postoperative cognitive dysfunction is a clinical entity that is associated with poor outcome. We determined the effectiveness of amantadine in reducing surgery-induced cognitive impairment and the role of glial cell line-derived neurotrophic factor (GDNF) in this effect. METHODS Four-month old male Fischer 344 rats were subjected to right carotid exposure under intravenous anesthe...

2013
Aida Attar Tingyu Liu Wai-Ting Coco Chan Jane Hayes Mona Nejad KaiChyuan Lei Gal Bitan

Alzheimer's disease is a progressive neurodegenerative disease that manifests as memory loss, cognitive dysfunction, and dementia. Animal models of Alzheimer's disease have been instrumental in understanding the underlying pathological mechanism and in evaluation of potential therapies. The triple transgenic (3 × Tg) mouse model of AD is unique because it recapitulates both pathologic hallmarks...

2014
Jason S. Cheng Ryan Craft Gui-Qiu Yu Kaitlyn Ho Xin Wang Geetha Mohan Sergey Mangnitsky Ravikumar Ponnusamy Lennart Mucke

OBJECTIVE Because reduction of the microtubule-associated protein Tau has beneficial effects in mouse models of Alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (TBI). METHODS We adapted a mild frontal impact model of TBI for wildtype C57Bl/6J mice and characterized the behavioral deficits it causes in t...

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