The RIZ (G3B/MTB-Zf) gene was first isolated based on its ability to bind to the retinoblastoma protein (Rb). An acidic, approximately 100-amino-acid region around the Rb-binding motif of RIZ has structural and antigenic similarity to the conserved sequences of the E1A viral oncogene. We show here that this region interacts specifically with the E1A-binding domain of Rb. This interaction could ...

Many lines of evidence suggest that the retinoblastoma protein interacting zinc finger gene RIZ is a strong candidate for the tumor suppressor locus on 1p36, a region commonly deleted in many human cancers with chromosomal instability. In addition, a role for RIZ in tumors of the microsatellite instability pathway is suggested by frequent frameshift mutations in hereditary non-polyposis colorec...

Mutations or changes in protooncogenes and tumor suppressor genes are casually linked to human cancer pathogenesis. The RIZ gene is isolated based on the capacity its gene products to bind to the retinoblastoma tumor suppressor protein. Consistent with a potential role in the Rb pathway, RIZ may play an important role in human cancer pathogenesis. RIZ maps to human chromosome band 1p36, a regio...

this research carried out in the rafsanjan pistachio orchard to investigate the effect of n form, manure, k and fe on yield, nut quality and leaf mineral nutrients concentrations of pistacia vera l. cv. fandoghi grafted on badami-riz zarand rootstock. the experiment was as factorial with four factors including; manure (without manure and 10 kg tree-1 sheep manure), n form (ammonium sulfate and ...

This study implements and tests a mathematical programming model to estimate interregional, interindustry transaction flows in a national system of economic regions based on an interregional accounting framework and initial information of interregional shipments. A national input-output (IO) table, regional data on gross output, value-added, exports, imports and final demand at sector level are...

We use detailed ethnographic evidence to design and interpret a broad representative survey of 800 households in Delhi’s slums, examining the processes by which residents gain access to formal government and develop their own, informal, modes of leadership. While ethnically homogeneous slums transplant rural institutions to the city, newer and ethnically diverse slums depend on informal leaders...

If the Internet made it easier for firms to enter new markets by reducing communication and search costs then it may also have made it easier to export goods and services. We find that higher Internet penetration in developing countries is correlated with greater exports to developed countries, but not with trade between developing countries or with exports from developed countries. Interpretin...

Instead of mean-tested Conditional Cash Transfer (CCT) programs, some countries have implemented gender-targeted CCTs to explicitly address intra-household disparities in human capital investments. This study focuses on addressing the direct impact of a female school stipend program in Punjab, Pakistan – Did the intervention increase female enrollment in public schools? To address this question...