نتایج جستجو برای: bacterial barrier

تعداد نتایج: 291925  

2016
Elena Kostadinova Catherine Chaput Birgitt Gutbier Juliane Lippmann Leif E. Sander Timothy J. Mitchell Norbert Suttorp Martin Witzenrath Bastian Opitz

Bacterial pneumonia is a major cause of acute lung injury and acute respiratory distress syndrome, characterized by alveolar barrier disruption. NLRP3 is best known for its ability to form inflammasomes and to regulate IL-1β and IL-18 production in myeloid cells. Here we show that NLRP3 protects the integrity of the alveolar barrier in a mouse model of Streptococcus pneumoniae-induced pneumonia...

Journal: :JPEN. Journal of parenteral and enteral nutrition 2010
Rosana das Graças Carvalho dos Santos Mirelle Lomar Viana Simone Vasconcelos Generoso Rosa Esteves Arantes Maria Isabel Toulson Davisson Correia Valbert Nascimento Cardoso

BACKGROUND Glutamine (GLN) is the preferred fuel for enterocytes, and GLN supplementation is critical during stressful conditions. The aim of this study was to evaluate the effect of GLN on intestinal barrier permeability and bacterial translocation in a murine experimental model. METHODS Swiss male mice (25-30 g) were randomized into 3 groups: (1) sham group; (2) intestinal obstruction (IO) ...

Journal: :The Journal of investigative dermatology 2016
Charles W Bradley Daniel O Morris Shelley C Rankin Christine L Cain Ana M Misic Timothy Houser Elizabeth A Mauldin Elizabeth A Grice

Host-microbe interactions may play a fundamental role in the pathogenesis of atopic dermatitis, a chronic relapsing inflammatory skin disorder characterized by universal colonization with Staphylococcus species. To examine the relationship between epidermal barrier function and the cutaneous microbiota in atopic dermatitis, this study used a spontaneous model of canine atopic dermatitis. In a c...

Journal: :Advanced Drug Delivery Reviews 2021

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and targets are urgently needed. Bacterial uptake, distribution, metabolic efflux pathways antibiotics in Gram-negative bacteria determine what we here refer to as bacterial bioavailability. Understanding these mechanisms from a chemical perspective is essential for anti-infective activity hence, drug dis...

2017
Elisabet Sánchez Juan C. Nieto Silvia Vidal Alba Santiago Xavier Martinez Francesc J. Sancho Pau Sancho-Bru Beatriz Mirelis Helena Corominola Candido Juárez Chaysavanh Manichanh Carlos Guarner German Soriano

Probiotics can prevent pathological bacterial translocation by modulating intestinal microbiota and improving the gut barrier. The aim was to evaluate the effect of a fermented milk containing Lactobacillus paracasei subsp. paracasei CNCM I-1518 on bacterial translocation in rats with carbon tetrachloride (CCl4)-induced cirrhosis. Sprague-Dawley rats treated with CCl4 were randomized into a pro...

Journal: :Proceedings of the National Academy of Sciences 2018

2010
Ursula Hofer Erika Schlaepfer Stefan Baenziger Marc Nischang Stephan Regenass Reto Schwendener Werner Kempf David Nadal Roberto F. Speck

Bacterial translocation from the gut and subsequent immune activation are hallmarks of HIV infection and are thought to determine disease progression. Intestinal barrier integrity is impaired early in acute retroviral infection, but levels of plasma lipopolysaccharide (LPS), a marker of bacterial translocation, increase only later. We examined humanized mice infected with HIV to determine if di...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Takeshi Inagaki Antonio Moschetta Youn-Kyoung Lee Li Peng Guixiang Zhao Michael Downes Ruth T Yu John M Shelton James A Richardson Joyce J Repa David J Mangelsdorf Steven A Kliewer

Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic infection. These adverse effects of biliary obstruction can be inhibited by administration of bile acids. Here we show that the farnesoid X receptor (FXR), a nuclear receptor for bile acids, induces genes ...

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