OBJECTIVE We have reported further heterogeneity in familial autosomal-dominant hypercholesterolemia (FH) related to mutation in proprotein convertase subtilisin/kexin type 9 (PCSK9) gene previously named neural apoptosis regulated convertase 1 (Narc-1). Our aim was to define the metabolic bases of this new form of hypercholesterolemia. METHODS AND RESULTS In vivo kinetics of apolipoprotein B...

PURPOSE To study racemic bupivacaine, non-racemic bupivacaine and ropivacaine on myocardial contractility. METHODS Isolated Wistar papillary muscles were submitted to 50 and 100 mM racemic bupivacaine (B50 and B100), non-racemic bupivacaine (NR50 and NR100) and ropivacaine (R50 and R100) intoxication. Isometric contraction data were obtained in basal condition (0.2 Hz), after increasing the f...

Abstract Emissions from a diesel engine are dangerous to the environment and human health. Substitutable fuels renewable source one of alternatives reduce emissions. Neat biodiesel based palm oil (B100) can emissions higher oxygen content be more complete combustion. The disadvantage neat is lower thermal efficiency an advancement ignition. To improve this problem, adding bioethanol produced ag...

he paper provides data on the strength and deformation characteristics of heavy self-compacting concrete classes B30-B100 with a cubic compressive 36.5-114.8 MPa. It has been established that values prism (36.2-104.2 MPa) are 42-64% higher than normalized given in building code Russian Federation SP 63.13330.2018. The static modulus elasticity for high-strength concretes B80-B100 44.1-48.1 GPa ...

Background and Aim of Study: Dyslipidemia is a risk factor for cardiovascular disease, lipid metabolism changes are linked to essential hypertension. The aim the study: investigate significance parameters, apolipoproteins, their ratio in predicting disease among individuals with Material Methods: 250 patients hypertension healthy control subjects were enrolled this case-control study serum lipi...

Hunger for energy consumption is booming due to industrialization and globalization causes the of fossil fuel resources searching unconventional fuels. Among all other available fuels, biodiesel has achieved significant considerations globally. The present research catering production from eucalyptus species as forest waste using fast pyrolysis. derived was tested its various physical chemical ...

BACKGROUND Changing the fuel supply from petroleum based ultra-low sulfur diesel (ULSD) to biodiesel and its blends is considered by many to be a viable option for controlling exposures to particulate material (PM). This is critical in the mining industry where approximately 28,000 underground miners are potentially exposed to relatively high concentrations of diesel particulate matter (DPM). T...

Epidemiologic studies suggest that the consumption of red wine may lower the risk of cardiovascular disease. The cardioprotective effect of red wine has been attributed to the polyphenols present in red wine, particularly resveratrol (a stilbene, with estrogen-like activity), and the flavonoids, catechin, epicatechin, quercetin and phenolic acids such as gallic acid. At present, very little is ...

The finitude and environmental impact of petroleum fuels have led to the search alternative biodiesel has proven be an fuel petro-diesel with less impact. Engine performance exhaust emissions Sandbox Methyl Ester (SBME) were evaluated. Pure SBME (B100) was blended diesel at 5, 10, 15, 20, 25 50% volume designated B5, B10, B15, B20, B25 B50 respectively. used as a reference fuel. blends (B100-B5...