Endophilin-B1, also known as Bax-interacting factor 1 (Bif-1, and encoded by SH3GLB1), is a multifunctional protein involved in apoptosis, autophagy and mitochondrial function. We recently described a unique neuroprotective role for neuron-specific alternatively spliced isoforms of endophilin-B1. To examine whether endophilin-B1-mediated neuroprotection could be a novel therapeutic target for A...

Perception of photoperiod changes enables plants to flower under optimum conditions for survival. We used doubled haploid populations of crosses among Avalon × Cadenza, Charger × Badger and Spark × Rialto and identified short-day flowering time response quantitative trait loci (QTL) on wheat chromosomes 1BS and 1BL. We used synteny between Brachypodium distachyon and wheat to identify potential...

A human B-cell lymphoma xenograft model was used to test whether the administration of unlabeled MoAb prior to injection of radiolabeled monoclonal antibody (MoAb) improves delivery of the radiolabeled MoAb to tumor prior to testing in clinical radioimmunotherapy trials. The anti-B1/CD20 pan-B-cell MoAb reactive with human B-cell lymphomas and leukemias but not reactive with mouse B-cells was u...

PURPOSE: The BEAR method is a recently proposed phase-based B1 mapping method. An important feature of BEAR is that the phase sensitivity to B1 can be manipulated with sequence parameters. We describe a new method that calculates the B1 distribution in a volume from multiple 1D BEAR projections, where each projection has a different B1 sensitivity. In essence, we are replacing spatial phase enc...

PURPOSE Cyclin B1 plays an important role as a mitotic cyclin in the G(2)-M phase transition during the cell cycle. The aim of the present study was to elucidate the biological significance of cyclin B1 expression in squamous cell carcinoma (SCC) of the esophagus. EXPERIMENTAL DESIGN We analyzed immunohistochemically the expression of cyclin B1 in the tumor specimens from 120 patients with SC...

A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated suggests that some B cells fulfill other roles in autoimmunity. We examined the recently identified human B1 cell population for T cell stimulatory activity. We found two kinds of B1 cells that are distinguished by...

Fusarium moniliforme (F. moniliforme) is one of the most frequent fungal pathogens found in rice. Samples of rice grown in three different zones of Mazandaran Province, Iran were collected and analyzed for the presence of fumonisin B (FB ). Mycological analysis revealed the presence of F. moniliforme-type isolates 1 1 in 65.1% of the rice samples. Average levels of FB per zones 1, 2 and 3 were ...