We present the first detailed expression profiles of nonprimate-derived adeno-associated viruses, namely, bovine adeno-associated virus (B-AAV) and avian adeno-associated virus (A-AAV), which were obtained after the infection of cell lines derived from their natural hosts. In general, the profiles of B-AAV and A-AAV were quite similar to that of AAV5; however, both exhibited features found for ...

REP 2139 is a nucleic acid polymer (NAP) currently under clinical development for chronic hepatitis B (HBV) therapy. This preclinical study investigated different REP 2139 analogs that would display reduced accumulation in the serum and tissues, while retaining an antiviral effect against HBV infection. REP 2139 analogs were evaluated in human plasma, CD-1 mice, cynomolgus monkeys, and Pekin du...

Repetitive element polymorphism-PCR (REP-PCR) is one of the tools that has been used to elucidate genetic diversity of related microorganisms. Using the MB1 primer, REP-PCR fingerprints from 110 Bacillus strains within the "B. cereus group" have identified eighteen distinct categories, while other more distantly related bacterial species fell within six additional categories. All Bacillus anthr...

Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]40, containing TLR9-stimulatory CpG; REP 2055 a clinically active NAP with a s...

The authors are investigating reverse engineering for reconstructing the shape of simple mechanical parts. Currently, preliminary B-rep models can be created by fitting surfaces to point clouds obtained by scanning an actual part using a 3D laser scanner. The resulting model, although valid, is often not suitable for purposes such as redesign. This is because expected regularities and constrain...

ninety one monoconidial bipolaris isolates were obtained from lesions on different parts of rice in different locations of mazandaran province during the summer of 2009. bipolaris species were identified using morphological features such as color and shape of colony and color and size of conidia and conidiophores. the isolates were separated into two species; 85 (93.4%) isolates belonged to bip...

 In general geometric models, the design of objects is usually separated from the manufacture  At the present, two general solid modeling representations dominate: B-REP (Boundary representation) and CSG (Constructive Solid Geometry)  They have some drawbacks:  The design of complex objects is usually complicated.  CSG: limited number of primitives for free surfaces design  B-REP: modific...

Repetitive-element PCR (rep-PCR) with primers based on repetitive extragenic palindromic (REP) and enterobacterial repetitive intergenic consensus (ERIC) repeated DNA sequences was used for genomic finger-printing of Bartonella species. This technique was applied by using either extracted genomic DNA or preparations of whole bacterial cells directly. PCR fingerprints with either the REP-based p...