The traditional Staudinger/aza-Wittig reaction represents one of the most powerful tools for imine formation. However, this multistep procedure, sacrificial phosphine has to be used, resulting in difficulties purification process and waste disposal at same time. Here, we report a redox-neutral azide–alcohol imination methodology enabled by base-metal nickel PN3 pincer catalyst. one-step, waste-...

The title compound, C(19)H(21)N(3)O(3)S, was synthesized via the aza-Wittig reaction of functionalized imino-phospho-rane with phenyl isocyanate under mild conditions. In the mol-ecule, the fused thienopyrimidine ring system is essentially planar, with a maximum deviation of 0.072 (2) Å, and makes a dihedral angle of 60.11 (9)° with the phenyl ring. An intra-molecular C-H⋯O hydrogen bond is pre...

A fast and efficient protocol for the synthesis of N,N'-disubstituted urea derivatives from alkyl halides and primary or secondary amines has been developed. The synthetic pathway combines nucleophilic substitutions and a Staudinger-aza-Wittig reaction in the presence of polymer-bound diphenylphosphine under 14 bar of CO2 pressure and has been performed in a one-pot two-step process. The protoc...

In the title compound, C(22)H(17)N(3)O(5), synthesized via the aza-Wittig reaction of ethyl 3-(phenyl-imino-methyl-ene-amino)-benzofuran-2-carboxyl-ate, benzene isocyanate and diethyl 2-amino-succinate, the imidazo[1,2-a]benzo[4,5]furo[2,3-d]pyrim-idine ring system is essentially planar (r.m.s. deviation for all 16 non-H atoms = 0.020 Å). The phenyl ring is twisted with respect to this ring sys...

The title compound, C(19)H(21)N(3)O(3)S, was synthesized via an aza-Wittig reaction of a functionalized imino-phospho-rane with phenyl isocyanate under mild conditions. In the mol-ecule, the fused thienopyrimidine ring system makes a dihedral angle of 66.30 (11)° with the phenyl ring. An intra-molecular C-H⋯O hydrogen bond occurs. The terminal -OCH(2)CH(3) group is disordered over two sites wit...