autosomal dominant polycystic kidney disease (adpkd) is the most common form of inherited kidney disease that results in renal failure. pkd currently has no causative therapy. however, some treatment options are available, ranging from symptomatic therapy to delaying the onset of end-stage renal failure. early diagnosis of adult polycystic kidney disease is vital in order to prevent its complic...

Sir, The review article by Dr. Badani and colleagues entitled “Autosomal dominant polycystic kidney disease and paina review of the disease from aetiology, evaluation, past surgical treatment options to current practice” is an interesting one. However, it is silent on the role of radiology. Radiology plays an important role in diagnosis of complications in autosomal dominant polycystic kidney d...

Renal cell carcinoma (RCC) in autosomal dominant polycystic kidney disease (ADPKD) is very rare. Only 11 cases of bilateral RCC in ADPKD have been reported since 1954. Herein, we present a 58-year-old male who received laparoscopic bilateral radical nephrectomy for bilateral RCC with different cell variants in ADPKD and end-stage renal disease under regular hemodialysis.

Polycystic liver disease (PLD) is characterized by the presence of multiple bile duct-derived epithelial cysts scattered in the liver parenchyma. PLD can manifest itself in patients with severe autosomal dominant polycystic kidney disease (ADPKD). Isolated autosomal dominant polycystic liver disease (ADPLD) is genetically distinct from PLD associated with ADPKD, although it may have similar pat...

Congenital Hepatic Fibrosis (CHF) is a rare disease that affects both the liver and kidneys.  Congenital hepatic fibrosis (CHF) is an autosomal recessive inherited malformation defined pathologically by a variable degree of periportal fibrosis and irregularly shaped proliferating bile ducts. Affected individuals also have impaired renal function, usually caused, in children and teenagers, by an...

Autosomal dominant polycystic kidney disease (ADPKD) is caused by a mutation in the disease1 (PKD1) gene, which responsible for 85% of ADPKD cases. The PKD1 gene encodes polycystin-1 (PC1) protein that has large extracellular area containing many polypeptide motifs. region PC1 includes several well-defined peptide domains show it been involved cell-cell and/or cell-matrix interactions. One regi...

BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder. In most cases, ADPKD similarly affects bilateral kidneys. CASE PRESENTATION Among the 605 ADPKD patients that were followed up by our center, we identified two male patients with unilateral ADPKD. The cases were remarkable because the patients also had ectopia and multicystic dysplasi...

Polycystic kidney disease in Persian cats culminates in chronic renal failure after a variable clinical course. An affected 6-year-old Persian cat was used to establish a colony of cats with polycystic kidney disease. In affected cats, cysts could be detected by ultrasonography as early as 7 weeks of age. Absence of cysts on ultrasound examination at 6 months of age was correlated with absence ...

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease. It is characterized by relentless development of kidney cysts, hypertension, and eventually end-stage renal disease (ESRD). ADPKD is associated abdominal fullness and pain, cyst hemorrhage, nephrolithiasis, cyst infection, hematuria, and reduced quality of life, among other symptoms. The disease is...