objective(s): abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ali). to identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (lps)-induced ali, we decided to evaluate autophagy (by lc3-ii and autophagosome) and apoptosis (by caspase-3) at different time point...

Summary: SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA associated with cancer pathogenesis. It contributes to a variety of cellular functions and recent evidence propounds its association with autophagy process. It has been showed that SOX2OT can regulate the expression of different autophagy associated factors in human cells with different mechanisms, however more remains to ...

Background and Aims: Oncolytic reoviruses can infect and kill malignant cells while sparing their normal counterparts. Reoviral infection can induce or activate autophagy, even though metformin can induce autophagy. Identifying and regulating the cellular pathways important for reovirus replication and oncolysis can improve targeted-biological therapies for cancer. Here, the autophagic process ...

Autophagy is a cellular recycling program that serves as crucial survival pathway and controls inflammatory responses in context-dependent manner. Here we demonstrate ablation of autophagy selectively keratinocytes, results exacerbated skin higher sensitivity to tumour formation. Autophagy-deficient keratinocytes are markedly sensitized apoptosis single-cell RNA-sequencing age-matched with auto...

background: the aim of this study was to clarify the mechanism by which lactobacilli exert their cytotoxic effects on cervical cancer cells. in addition, we aimed to evaluate the effect of lactobacilli on the expression of human papilloma virus (hpv) oncogenes. materials and methods: in this experimental study, using quantitative real-time polymerase chain reaction (pcr), we analyzed the expres...

Cigarette smoking is growing and nicotine is considered as the most adverse agent in the cigarette smoking. Nicotine is an alkaloid and forms 90% of alkaloids of cigarette. Nicotine is accountable for creating disorders and cancers such as lung cancer, heart disease and chronic lung disease. Nicotine can be considered as an autophagy and apoptosis inducer which can either directly or indirectly...

asthma is one of the fastest growing syndromes in many countries and is adding a huge cost to the health care system. increasing reports have linked airway infectious diseases to asthma. influenza is one of the most serious airway infectious diseases and in recent years there have been some serious influenza virus pandemics which caused increased fatality in numerous different populations. dive...

Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...

Objective(s): The aim of this study was to explore the effects of Squid ink polysaccharide (SIP) on prevention of autophagy and oxidative stress induced by cyclophosphamide (CP) in Leydig cells of mice. Materials and Methods: Examination of reproductive organ exponents, abnormal sperm rate, activities of superoxide dismutase (SOD), catalase (CAT), contents of malondialdehyde (MDA), and histolog...