Van Nes rotationplasty is a reconstructive and salvage procedure of the lower limb. The technique replaces the amputated thigh and knee with an autologus biological 'prosthesis', the patient's own ipsilateral ankle, which is rotated 180 degrees and fixed at the level of the contralateral knee. This procedure was first adapted by Borggreve of Germany in 1930 to treat a knee joint destroyed by tu...

Cultures of human epidermal keratinocytes provide a useful experimental model with which to study the factors that regulate cell proliferation and terminal differentiation. One situation that is known to trigger premature terminal differentiation is suspension culture, when keratinocytes are deprived of substratum and intercellular contact. We have now investigated whether area of substratum co...

The terminal differentiation of epithelial keratinocytes has been proposed to be a specialized form of programmed cell death (apoptosis). We examined the time correlation of apoptosis and terminal differentiation by human ectocervical keratinocytes in a suspension culture that induces either of these events in epithelial cells. We found that a loss of cell anchorage did not result in the immedi...

introduction: laryngotracheal stenosis can be caused after traumatic injuries to the neck from the subglottic larynx to the trachea. patients with laryngotracheal stenosis often need a tracheotomy and occasionally may become tracheotomy dependent. different procedures have been described for the management of these lesions. management options include techniques of endoscopic dilation, laser res...

Background: Hair follicle stem cells (HFSCs) located in the bulge area has shown to be highly proliferative and could differentiate into neurons, glia, smooth muscle cell, and melanocytes in vitro. Simvastatin is an HMG-CoA reductase inhibitor that exerts pleiotropic effects beyond simple low-density lipoprotein lowering and has a similar impact on the differentiation of bone marrow stromal cel...

stem cells are the cells having some distinguishing characteristics like longevity, high capacity of self-renewal and differentiation, quiescence and highly error-free proliferation. almost all stem cells have the potential of lineage reprogramming, i.e. inter-conversion of cell lineages. they also have the potential to differentiate into almost all kinds of cells. these cells have been found i...