The idiopathic inflammatory myopathies are chronic autoimmune disorders sharing the clinical symptom of muscle weakness and, in typical cases, inflammatory cell infiltrates in muscle tissue. During the last decade, novel information has accumulated supporting a role of both the innate and adaptive immune systems in myositis and suggesting that different molecular pathways predominate in differe...

The general aim of this study was to evaluate the disease spectrum in patients presenting with a pure polymyositis (pPM) phenotype. Specific objectives were to characterize clinical features, autoantibodies (aAbs), and membrane attack complex (MAC) in muscle biopsies of patients with treatment-responsive, statin-exposed necrotizing autoimmune myositis (NAM). Patients from the Centre hospitalier...

Inflammatory myopathies are the largest group of potentially treatable myopathies in children and adults. They constitute a heterogeneous group of disorders that are best classified, on the basis of distinct clinicopathologic features, in four subtypes: dermatomyositis, polymyositis, necrotizing autoimmune myositis, and inclusion-body myositis (throughout this review, I use this term to refer s...

Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the clinical course of myositis reflects that of cancer and the short delay betwe...

Idiopathic inflammatory myopathies are a group of autoimmune diseases characterized by proximal muscle weakness and inflammation of skeletal muscle. Specific forms of idiopathic inflammatory myopathy include polymyositis, dermatomyositis, and inclusion body myositis. Inflammatory myopathies have a bimodal distribution, occurring in patients between 10 and 15 years and 45 and 60 years of age, ex...

INTRODUCTION Recurrent myositis triggered by infections is unusual, with only one other case reporting two attacks described in the literature. CASE PRESENTATION We report the case of a 24-year-old Caucasian woman with recurrent myositis triggered by sore throat, respiratory and urinary tract infections, over the past 18 years, up to four times a year. Myositis of this frequency and duration,...

Inflammatory myopathies are a group of autoimmune diseases that affect muscles. In humans, the most common inflammatory myopathies are polymyositis, dermatomyositis, and inclusion body myositis. Autoantibodies may be found in humans with inflammatory myopathies, and these play an important role in diagnosis and disease classification. However, these Abs are typically not muscle specific. Sponta...

The idiopathic inflammatory myopathies (IIM), classically dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM), are acquired systemic autoimmune disorders defined by chronic muscle weakness and inflammation of unknown aetiology. The combination of clinical, laboratory, electromyographic, and histological features is the basis of diagnosis, as well as exclusion of several m...

Background Autoantibodies against cN-1A (Mup44) are primarily used as a biomarker for inclusion body myositis (IBM), they also occur with lower prevalence in systemic lupus erythematosus (SLE) and Sjögren’s Syndrome (SjS). has been included parameter on the multiparameter lineblot Autoimmune Inflammatory Myopathies 16 Ag et (EUROIMMUN), allowing detection of 17 myositis-specific myositis-associ...